Metarin Tablet 500 mg contains Metformin Hydrochloride, a first-line oral antidiabetic medicine used for the management of type 2 diabetes mellitus. It helps control blood sugar levels by improving insulin sensitivity and reducing glucose production in the liver.

This medicine is widely used as part of a comprehensive diabetes management plan, including diet and exercise.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Metformin Hydrochloride
• Strength: 500 mg
• Dosage Form: Oral tablet

Mechanism of Action

Metformin works through multiple mechanisms to control blood glucose:

• Decreases hepatic glucose production (gluconeogenesis)
• Increases insulin sensitivity in peripheral tissues
• Improves glucose uptake and utilization
• Reduces intestinal absorption of glucose

It does not stimulate insulin secretion, thereby lowering the risk of hypoglycemia when used alone.

Indications

Metarin Tablet 500 mg is indicated for:

• Type 2 diabetes mellitus
• Management of insulin resistance
• Polycystic ovary syndrome (PCOS) (as prescribed)
• Adjunct therapy in metabolic disorders

Dosage and Administration

• Use only as directed by a physician
• Usually taken with meals to reduce gastrointestinal side effects
• Dosage is individualized based on blood glucose response
• Swallow whole with water
• Regular monitoring of blood sugar levels is recommended

Benefits

• Effectively lowers blood glucose levels
• Improves insulin sensitivity
• Helps reduce risk of diabetes-related complications
• Does not typically cause weight gain
• Suitable for long-term diabetes management
• Well-established first-line therapy

Side Effects

Common side effects may include:

• Nausea
• Diarrhea
• Abdominal discomfort
• Loss of appetite
• Metallic taste in mouth

Less common but serious effects:

• Lactic acidosis (rare but serious)
• Vitamin B12 deficiency with long-term use
• Hypoglycemia (rare when used alone)

Precautions and Warnings

• Use only under medical supervision
• Monitor kidney function regularly
• Avoid in severe renal or hepatic impairment
• Temporarily discontinue before contrast imaging procedures (as advised)
• Use cautiously in elderly patients

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Pregnancy: Use only if clearly needed (often continued in gestational diabetes under supervision)
• Lactation: Generally considered safe
• Pediatrics: Use under specialist guidance
• Elderly: Requires renal monitoring

Storage

• Store below 25°C
• Protect from moisture and light
• Keep in original packaging
• Keep out of reach of children.