Metanib Tablet 400 mg contains Imatinib Mesylate, a targeted anticancer medication used in the treatment of certain types of leukemia and other malignancies. It belongs to a class of medicines known as tyrosine kinase inhibitors (TKIs). Metanib works by specifically targeting abnormal proteins responsible for uncontrolled cancer cell growth. It is widely used in the management of chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST), among other conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Imatinib Mesylate equivalent to Imatinib 400 mg per tablet

Indications

Metanib Tablet 400 mg is indicated for the treatment of:

• Philadelphia chromosome-positive Chronic Myeloid Leukemia (CML)

• Acute Lymphoblastic Leukemia (Ph+ ALL)

• Gastrointestinal Stromal Tumors (GIST)

• Myelodysplastic/Myeloproliferative diseases

• Certain rare tumors driven by specific tyrosine kinase mutations

It is prescribed based on confirmed diagnosis and molecular testing.

Mechanism of Action

Imatinib works by inhibiting specific tyrosine kinase enzymes such as BCR-ABL, c-KIT, and PDGFR. In CML, the abnormal BCR-ABL protein promotes uncontrolled growth of white blood cells. Metanib blocks this abnormal signaling pathway, thereby slowing or stopping the proliferation of cancer cells.

In GIST and other tumors, it inhibits mutated receptor tyrosine kinases responsible for tumor growth. By targeting cancer cells specifically, Metanib helps control disease progression while minimizing damage to normal cells.

Dosage and Administration

• The usual dose for adults is 400 mg once daily, but dosage may vary depending on the condition and patient response.

• The tablet should be taken with a meal and a large glass of water to reduce gastric irritation.

• Do not crush or chew the tablet.

• Treatment duration depends on the disease type and clinical response.

Always follow your oncologist’s instructions carefully.

Benefits

• Targeted therapy for specific cancers

• Helps control disease progression

• Improves survival outcomes in CML and GIST

• Oral administration for convenient long-term therapy

• Proven efficacy in molecularly driven cancers

Precautions

• Regular blood tests are required to monitor blood counts and liver function.

• Inform your doctor if you have liver, kidney, or heart problems.

• Use effective contraception during treatment, as it may cause harm to an unborn baby.

• Avoid grapefruit and grapefruit juice during therapy.

• Not recommended during pregnancy or breastfeeding unless clearly advised.

Possible Side Effects

Common side effects may include:

• Nausea or vomiting

• Fluid retention or swelling

• Muscle cramps

• Fatigue

• Diarrhea

• Skin rash

Serious side effects such as severe fluid retention, liver toxicity, or low blood counts require immediate medical attention.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Imatinib may interact with certain antifungals, antibiotics, anticoagulants, and other anticancer agents. Inform your healthcare provider about all medicines and supplements you are taking.

Storage Instructions

• Store below 30°C in a dry place.

• Protect from light and moisture.

• Keep out of reach of children.

Conclusion

Metanib Tablet 400 mg (Imatinib Mesylate) is an effective targeted therapy used in the treatment of CML, GIST, and other specific cancers. Under proper medical supervision, it helps control disease progression and improve patient outcomes with a convenient oral dosing regimen.