Mabrix Injection 10 mg/ml contains Rituximab, a monoclonal antibody used in the treatment of certain autoimmune diseases and cancers, particularly B-cell non-Hodgkin’s lymphoma and chronic lymphocytic leukemia. Rituximab works by specifically targeting CD20-positive B lymphocytes, leading to their destruction. Mabrix is also used in select autoimmune conditions to help modulate an overactive immune response, providing targeted therapy with proven efficacy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each ml of solution contains:

• Rituximab 10 mg/ml

Key Benefits

• Targets and destroys CD20-positive B cells
• Effective in treating B-cell malignancies
• Modulates immune response in autoimmune conditions
• Reduces disease activity and progression
• Administered intravenously for precise dosing and control

Indications

Mabrix Injection 10 mg/ml is indicated for:

• Non-Hodgkin’s lymphoma (NHL)
• Chronic lymphocytic leukemia (CLL)
• Rheumatoid arthritis (in combination with methotrexate, in select cases)
• Certain autoimmune diseases as advised by a physician

Mechanism of Action

Rituximab is a chimeric monoclonal antibody that binds specifically to the CD20 antigen on B lymphocytes. Its action involves:

• Inducing B-cell lysis through complement-dependent cytotoxicity (CDC)
• Triggering antibody-dependent cell-mediated cytotoxicity (ADCC)
• Promoting apoptosis of malignant or autoreactive B cells

This selective targeting helps reduce disease activity while sparing other immune cells.

Dosage & Administration

• Administered only by a trained healthcare professional via intravenous infusion
• Dosage and schedule depend on the condition being treated and patient response
• Premedication with antihistamines, corticosteroids, or acetaminophen may be recommended to reduce infusion reactions
• Monitor for infusion-related reactions during administration

Precautions & Warnings

• Not for self-administration
• Monitor for severe infusion reactions, including fever, chills, or hypotension
• Risk of infections due to immunosuppression
• Use caution in patients with hepatitis B virus infection
• Regular monitoring of blood counts and liver function is recommended

Side Effects

Common side effects may include:

• Fever and chills
• Fatigue
• Headache
• Nausea or vomiting
• Infusion-related reactions (rash, hypotension, shortness of breath)

Serious side effects (require immediate medical attention):

• Severe infections
• Progressive multifocal leukoencephalopathy (PML)
• Severe allergic reactions
• Cytopenias (low blood cell counts)

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to Rituximab or any component of the formulation
• Active severe infections
• Caution in patients with significant immunosuppression

Storage

• Store at 2–8°C (refrigerated)
• Do not freeze
• Protect from light
• Keep out of reach of children.