Losart Plus Tablet 50 mg+12.5 mg is a fixed-dose combination of Losartan Potassium and Hydrochlorothiazide, formulated to effectively manage hypertension (high blood pressure). This dual-action therapy combines an angiotensin II receptor blocker (ARB) with a thiazide diuretic to provide enhanced blood pressure control compared to monotherapy.

Losartan Potassium works by selectively blocking the angiotensin II type 1 (AT1) receptor, preventing vasoconstriction and reducing the secretion of aldosterone. This results in relaxation of blood vessels and decreased blood pressure. Hydrochlorothiazide complements this action by promoting the excretion of excess sodium and water through urine, thereby reducing plasma volume and further lowering blood pressure.

Together, these two agents offer synergistic antihypertensive effects, making Losart Plus Tablet particularly suitable for patients whose blood pressure is not adequately controlled with Losartan alone.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Angiotensin II Receptor Blocker (ARB) + Thiazide Diuretic

• Antihypertensive Combination Therapy

Indications

Losart Plus Tablet is indicated for:

• Management of essential hypertension

• Patients not adequately controlled on Losartan monotherapy

• Reduction of cardiovascular risk associated with high blood pressure

• Hypertensive patients requiring combination therapy for optimal blood pressure control

Effective blood pressure management helps reduce the risk of stroke, myocardial infarction, and renal complications.

Pharmacology

Losartan Potassium selectively inhibits the binding of angiotensin II to the AT1 receptor found in vascular smooth muscle, adrenal glands, heart, and kidneys. By blocking this receptor, it prevents vasoconstriction and reduces aldosterone-mediated sodium and water retention.

Hydrochlorothiazide acts on the distal convoluted tubule of the kidney to inhibit sodium and chloride reabsorption. This increases urinary excretion of sodium, chloride, and water, which leads to decreased blood volume and reduced blood pressure.

The combination provides additive antihypertensive effects through complementary mechanisms.

Dosage & Administration

The usual recommended dose is one tablet once daily or as directed by the physician. Dosage should be individualized based on patient response and clinical condition.

It may be taken with or without food. Patients should follow their healthcare provider’s instructions carefully and continue treatment regularly for optimal results.

Contraindications

Losart Plus Tablet is contraindicated in:

• Patients hypersensitive to Losartan, Hydrochlorothiazide, or any component of the formulation

• Pregnancy, particularly during the second and third trimesters

• Severe renal impairment or anuria

• Patients with hypersensitivity to sulfonamide-derived drugs

Concomitant use with aliskiren in diabetic patients is not recommended.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Losart Plus is generally well tolerated. Common side effects may include:

• Dizziness

• Headache

• Fatigue

• Hypotension

• Increased urination

• Electrolyte imbalance

Most adverse effects are mild and transient. Patients should consult a physician if symptoms persist or worsen.

Precautions & Warnings

• Monitor renal function and electrolyte levels periodically.

• Use caution in patients with hepatic impairment.

• Risk of symptomatic hypotension may occur in volume-depleted individuals.

• Not recommended during pregnancy due to risk of fetal toxicity.

Pregnancy & Lactation

Losart Plus Tablet is contraindicated during pregnancy due to potential fetal harm. If pregnancy is detected, treatment should be discontinued immediately. Caution is advised during lactation, and medical advice should be sought before use.

Storage Conditions

Store in a cool, dry place away from heat and direct light. Keep out of reach of children.