Lopadine 0.1% is an ophthalmic solution formulated for the treatment of ocular itching associated with allergic conjunctivitis. It is a non-steroidal antihistamine eye drop that provides rapid relief from symptoms of eye allergy, including itching, redness, and irritation.

Lopadine 0.1% is widely used in patients with seasonal or perennial allergic conjunctivitis, offering a convenient and effective option for daily symptom management.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Ophthalmic Non-Steroid Drugs

Pharmacology

Lopadine 0.1% (Olopatadine) works by:

• Histamine H1 receptor antagonism: Blocks histamine-mediated allergic responses in the conjunctiva.

• Mast cell stabilization: Inhibits release of histamine and other inflammatory mediators from mast cells, preventing further allergic reactions.

Olopatadine is highly selective for H1 receptors and does not affect alpha-adrenergic, dopamine, or muscarinic receptors, reducing the risk of systemic side effects. Following ocular administration, systemic absorption is minimal.

Indications

Lopadine 0.1% is indicated for:

• Relief of ocular itching associated with allergic conjunctivitis

• Management of seasonal or perennial eye allergies

Dosage and Administration

• 0.1% Eye Drops: One drop in each affected eye twice daily, spaced 6–8 hours apart.

• 0.2% Eye Drops: One drop in the affected eye once daily.

• 0.7% Eye Drops: One drop in each affected eye once daily.

Special instructions:

• Remove contact lenses before administration.

• Wait at least 10 minutes after instillation before reinserting soft contact lenses.

Interaction

• Additive CNS depression may occur with CNS depressants.

Contraindications

• Known hypersensitivity to Olopatadine or any component of the ophthalmic solution.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common and mild side effects may include:

• Headache (~7% incidence)

• Burning or stinging sensation in the eyes

• Blurred vision

• Dry eye, pruritus, hyperemia

• Less common: asthenia, nausea, sinusitis, taste perversion, lid edema

Pregnancy and Lactation

• Use only if the potential benefit justifies the risk to the fetus.

• Caution is advised when administered to nursing mothers, as systemic absorption is minimal but unknown.

Precautions and Warnings

• Do not use for contact lens-related irritation.

• Avoid touching the dropper tip to any surface to prevent contamination.

Overdose

• Symptoms: Drowsiness in adults; agitation followed by drowsiness in children.

• Management: Supportive and symptomatic treatment.

Storage Conditions

• Store below 30°C in a cool, dry place, protected from light.

• Do not use after 30 days of first opening.

• Keep out of reach of children.

Use in Special Populations

• Geriatric Use: No significant differences in safety or effectiveness observed compared to younger adults.