Logibac 90 mg/5 ml Suspension contains Ceftibuten, a third-generation oral cephalosporin antibiotic indicated for the treatment of mild-to-moderate bacterial infections caused by susceptible organisms. It is particularly effective against respiratory tract infections, ear infections, throat infections, and certain urinary tract infections.

Ceftibuten is known for its stability against many beta-lactamase enzymes, allowing it to remain active against several bacteria that are resistant to penicillins and earlier-generation cephalosporins. The oral suspension formulation makes Logibac especially suitable for pediatric patients and individuals who have difficulty swallowing tablets or capsules.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Third Generation Cephalosporins

• Beta-lactam Antibiotics

Indications

Logibac 90 mg/5 ml is indicated for infections caused by susceptible strains of microorganisms in the following conditions:

• Acute bacterial exacerbations of chronic bronchitis caused by Haemophilus influenzae (including β-lactamase producing strains), Moraxella catarrhalis (including β-lactamase producing strains), and Streptococcus pneumoniae (penicillin-susceptible strains only)

• Acute bacterial otitis media due to Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pyogenes

• Pharyngitis and tonsillitis caused by Streptococcus pyogenes

• Acute bacterial sinusitis

• Community-acquired pneumonia (oral therapy appropriate cases)

• Urinary tract infections (complicated or uncomplicated)

• Acute bacterial enteritis (in children)

Pharmacology

Ceftibuten exerts its bactericidal action by inhibiting bacterial cell wall synthesis. It binds to essential penicillin-binding proteins (PBPs) within the bacterial cell wall, leading to structural damage and cell death.

Due to its chemical structure, Ceftibuten is highly stable to many beta-lactamases, making it effective against numerous resistant strains. It demonstrates strong activity against common respiratory and urinary pathogens.

Mode of Action

• Binds to penicillin-binding proteins (PBPs)

• Inhibits bacterial cell wall synthesis

• Causes bacterial cell lysis and death

• Maintains stability against beta-lactamase-producing organisms

Dosage & Administration

General Treatment Duration: 5–10 days
For Streptococcus pyogenes infections, treatment should continue for at least 10 days.

Adults:

• 400 mg once daily for bronchitis, sinusitis, otitis media, and urinary tract infections

• Pneumonia: 200 mg every 12 hours

• Duration varies by indication (7–14 days)

Children (>6 months):

• 9 mg/kg/day (maximum 400 mg daily), given once daily

• For acute enteritis: 4.5 mg/kg every 12 hours

• Children >45 kg or >10 years may receive the adult dose

Administration Instructions:

• Suspension may be taken 1–2 hours before or after meals

• Shake bottle well before each use

• After reconstitution, store in refrigerator (2°–8°C) and use within 14 days

Drug Interactions

• Theophylline and antacids: No significant effect

• Ranitidine: May increase Cmax and AUC of Ceftibuten

Contraindications

• Known hypersensitivity to cephalosporin antibiotics

Side Effects

Common adverse effects include:

• Nausea

• Diarrhea

• Headache

• Dyspepsia

• Dizziness

• Abdominal pain

• Vomiting

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions & Warnings

• Prolonged use may result in overgrowth of resistant organisms

• Use cautiously in patients with a history of gastrointestinal disease, especially colitis

• Dose adjustment required in renal impairment

• Monitor for signs of allergic reactions

Use in Special Populations

Renal Impairment:

• CrCl 30–49 mL/min: 200 mg daily

• CrCl 5–29 mL/min: 100 mg daily

• Hemodialysis patients: 400 mg after each session

Pediatric Use:

• Not established for infants under 6 months

Pregnancy & Lactation

• Pregnancy Category B

• Use only if clearly needed

• Acceptable during breastfeeding; low levels found in breast milk

Overdose

• May cause seizures

• Supportive treatment recommended

Storage Conditions

• Store below 25°C

• Protect from light and moisture

• Keep out of reach of children

• Reconstituted suspension should be refrigerated and used within 14 days.