Nokof DS Syrup 250 mg/5 ml is a double-strength mucolytic formulation containing Carbocisteine, designed to effectively manage respiratory conditions associated with excessive, thick, and tenacious mucus. This syrup helps reduce mucus viscosity and improves its clearance from the respiratory tract, thereby easing breathing and relieving productive cough. Nokof DS Syrup is suitable for both pediatric and adult patients who require a higher-strength mucolytic therapy under medical supervision.

By improving the quality and flow of bronchial secretions, Nokof DS Syrup supports better airway patency and enhances the effectiveness of cough, making it easier to expel mucus from the lungs.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন 

Indications

Nokof DS Syrup 250 mg/5 ml is indicated for the treatment of respiratory tract disorders characterized by abnormal or excessive mucus production, including:

• Acute bronchitis

• Chronic bronchitis

• Bronchial asthma with mucus hypersecretion

• Bronchiectasis

• Chronic obstructive pulmonary disease (COPD)

• Upper respiratory tract infections with productive cough

• Pneumonia and other lower respiratory tract infections requiring mucus drainage

Therapeutic Class

Cough Expectorants & Mucolytics

Pharmacology / Mode of Action

Carbocisteine, the active ingredient of Nokof DS Syrup, acts by regulating the composition of mucus in the respiratory tract. It reduces goblet cell hyperplasia, which contributes to excessive mucus secretion. Carbocisteine breaks the disulphide bonds that cross-link glycoprotein chains in thick sputum, leading to reduced viscosity.

Additionally, it restores the normal balance between sialomucins and fucomucins, resulting in thinner, less sticky mucus with increased volume. This improved mucus quality enhances mucociliary clearance, facilitates expectoration, and helps relieve airway obstruction.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন 

Dosage & Administration

Dosage should be individualized according to age, severity of illness, and clinical response, as directed by a physician.

• Nokof DS Syrup should be taken orally

• It is recommended to take the syrup with food to reduce gastrointestinal discomfort

• Adequate fluid intake is advised to enhance mucolytic action

Drug Interactions

No clinically significant or hazardous drug interactions have been reported with Carbocisteine. However, concurrent use with cough suppressants should be approached with caution, as suppression of cough may impair mucus clearance.

Contraindications

Nokof DS Syrup 250 mg/5 ml is contraindicated in patients with:

• Known hypersensitivity to Carbocisteine or any component of the formulation

• Active peptic ulcer disease

Side Effects

Nokof DS Syrup is generally well tolerated. Possible side effects include:

• Gastrointestinal discomfort

• Nausea or vomiting

• Diarrhea

• Heartburn

• Skin rash (rare)

Most side effects are mild and transient.

Pregnancy & Lactation

There are no adequate studies on the use of Carbocisteine during pregnancy and lactation. Nokof DS Syrup should be used during pregnancy only if clearly needed. Caution is advised when administering to breastfeeding mothers.

Precautions & Warnings

• Use with caution in patients with a history of peptic ulcer or gastrointestinal bleeding

• Do not exceed the prescribed dose

• If symptoms persist or worsen, medical advice should be sought

Storage Conditions

Store in a cool and dry place, protected from light and heat. Keep out of the reach of children.