LM 2.5 mg Tablet contains Levamlodipine, a calcium channel blocker (CCB) used to treat hypertension in adults and pediatric patients aged 6 years and older. Levamlodipine works by selectively inhibiting calcium ion influx into vascular smooth muscle and cardiac muscle, leading to vasodilation and a reduction in blood pressure. As a pharmacologically active isomer of amlodipine, Levamlodipine provides effective blood pressure control with a lower risk of adverse effects compared to racemic amlodipine.

LM 2.5 mg is ideal for patients requiring mild to moderate blood pressure management and can be used alone or in combination with other antihypertensive agents. Consistent blood pressure control with LM 2.5 mg reduces the risk of cardiovascular events, including strokes and myocardial infarctions, while improving overall vascular health.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Calcium Channel Blocker (Dihydropyridine)

Indications

LM 2.5 mg is indicated for:

• Hypertension in adults and children (6 years and older)

• Alone or in combination with other antihypertensive medications to achieve target blood pressure

• Prevention of fatal and nonfatal cardiovascular events, particularly strokes and heart attacks

Pharmacology

Mechanism of Action:

• Inhibits the transmembrane influx of calcium ions in vascular smooth muscle, causing arterial vasodilation

• Greater effect on vascular smooth muscle than cardiac muscle, minimizing negative cardiac effects

• Lowers systemic vascular resistance and reduces blood pressure

• Levamlodipine is the active enantiomer of amlodipine, responsible for its antihypertensive effects

Absorption & Distribution:

• Tmax: 6–12 hours

• Oral bioavailability: 64–90%

• Volume of distribution: 21 L/kg

• Food has minimal effect on absorption

Metabolism & Excretion:

• 90% metabolized by the liver, primarily via CYP3A4

• 60% excreted in urine, 10% as unchanged drug

Dosage and Administration

• Adults: Initial dose: 2.5 mg once daily; maximum: 5 mg once daily

• Elderly or hepatic impairment: Start at 1.25 mg once daily; titrate slowly

• Pediatric (6–17 years): 1.25–2.5 mg once daily; doses above 2.5 mg have not been studied

• Titration: Increase dose every 7–14 days based on blood pressure response, or faster if clinically required

• Administer orally, with or without food

Drug Interactions

• CYP3A inhibitors: May increase levamlodipine levels; dose adjustment may be needed

• Simvastatin: Co-administration increases simvastatin exposure; limit simvastatin to 20 mg daily

• Immunosuppressants: May increase cyclosporine or tacrolimus levels; monitor closely

• Avoid grapefruit products and natural licorice

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Known hypersensitivity to amlodipine or Levamlodipine

• Severe hypotension or shock

Possible Side Effects

• Common: Dizziness, hypotension, reflex tachycardia, edema, abdominal pain, difficulty breathing

• Rare: Headache, fatigue, diarrhea, back pain, nausea

Precautions

• Hypotension is possible, especially in patients with severe aortic stenosis

• May worsen angina or trigger myocardial infarction after initiation or dose increase

• Use cautiously in hepatic failure; titrate slowly due to prolonged half-life (t½ ~56 hours)

Overdose

• May cause excessive vasodilation, hypotension, and reflex tachycardia

• Supportive care is recommended; monitor vital signs

Pregnancy & Lactation

• Limited data in pregnancy; use only if benefits outweigh risks

• No observed adverse effects in breastfeeding infants

Storage

Store in a cool, dry place, protected from light and moisture. Keep out of reach of children.