Ligotin Tablet 12.5 mg contains Alogliptin Benzoate, a DPP-4 (Dipeptidyl Peptidase-4) inhibitor used for the management of type 2 diabetes mellitus. This oral antidiabetic medication helps control blood sugar levels in adults by enhancing the body’s natural ability to regulate glucose, making it an effective option for patients whose blood sugar is not adequately controlled by diet and exercise alone.

Alogliptin works by modulating incretin hormones, which are naturally released in response to food intake. By preserving incretin activity, Ligotin Tablet 12.5 mg increases insulin secretion during meals and reduces glucagon release, helping to stabilize postprandial and fasting blood glucose levels.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Mechanism of Action

Alogliptin Benzoate lowers blood glucose through a glucose-dependent mechanism:

• DPP-4 inhibition: Prevents the breakdown of incretin hormones (GLP-1 and GIP), prolonging their activity.

• Enhanced insulin secretion: Stimulates insulin release from pancreatic beta cells in response to elevated blood glucose.

• Suppression of glucagon: Reduces glucagon secretion from alpha cells, decreasing hepatic glucose production.

• Glucose-dependent action: Minimizes the risk of hypoglycemia because insulin is increased only when blood sugar is high.

This mechanism ensures effective glycemic control while maintaining a favorable safety profile.

Indications

Ligotin Tablet 12.5 mg is indicated for:

• Type 2 diabetes mellitus: As monotherapy when diet and exercise alone are insufficient.

• Combination therapy: Can be used with other oral antidiabetic agents, such as metformin or sulfonylureas, or with insulin, to achieve optimal glycemic control.

• Postprandial glucose control: Helps reduce spikes in blood sugar after meals.

It is not indicated for type 1 diabetes or for the treatment of diabetic ketoacidosis.

Dosage and Administration

• The usual adult dose is 12.5 mg once daily, orally, with or without food.

• Swallow the tablet whole with water.

• Dosage adjustment may be required in patients with renal impairment.

• Regular monitoring of blood glucose and HbA1c is recommended to assess efficacy.

• Continue following diet, exercise, and lifestyle modifications for best results.

Precautions

• Inform your doctor if you have kidney disease, liver disease, pancreatitis, or a history of hypersensitivity to DPP-4 inhibitors.

• Use caution in combination with sulfonylureas or insulin, as the risk of hypoglycemia may increase.

• Report signs of pancreatitis (severe abdominal pain, nausea, vomiting) promptly.

• Safety in pregnancy and lactation has not been established; consult your physician before use.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Ligotin Tablet 12.5 mg is generally well tolerated. Common side effects may include:

• Nasopharyngitis or upper respiratory tract infection

• Headache

• Mild gastrointestinal discomfort (nausea or diarrhea)

Rare but serious side effects include:

• Pancreatitis

• Hypersensitivity reactions (rash, swelling, or difficulty breathing)

• Severe joint pain

Patients should contact their healthcare provider if they experience unusual or severe symptoms.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Ligotin Tablet 12.5 mg offers effective and convenient management of type 2 diabetes, improving blood sugar control, supporting pancreatic function, and helping patients maintain long-term metabolic health under medical supervision.