Labegest 100 mg contains Labetalol Hydrochloride, a combined alpha- and beta-adrenergic blocker used to manage hypertension. By competitively inhibiting α1- and β-adrenergic receptors, Labegest reduces peripheral vascular resistance and heart rate, lowering blood pressure effectively without causing reflex tachycardia. It is suitable for managing a wide spectrum of hypertensive conditions, including pregnancy-induced hypertension, angina in hypertensive patients, catecholamine excess, pheochromocytoma, and hypertensive episodes during anesthesia.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Alpha- and Beta-Adrenoceptor Blocking Agent

Indications

Labegest 100 mg is indicated for:

• All grades of hypertension, including pregnancy-induced hypertension

• Angina in patients with hypertension

• Situations requiring controlled hypotension during anesthesia

• Management of catecholamine excess and pheochromocytoma

By controlling blood pressure without significant reflex tachycardia, Labegest provides stable hemodynamic control in acute and chronic hypertensive conditions.

Pharmacology

Labetalol acts through dual mechanisms:

1. β-Adrenoceptor Blockade: Reduces heart rate, cardiac output, and renin release, thereby lowering blood pressure.

2. α1-Adrenoceptor Blockade: Causes vasodilation and decreases peripheral resistance, reducing systolic and diastolic blood pressure.

Labetalol also exhibits mild β2 agonist activity and membrane-stabilizing properties. Its combined alpha- and beta-blocking effects allow effective blood pressure reduction without significant reflex tachycardia. The drug has minimal impact on cardiac conduction in most patients but may modestly prolong atrioventricular conduction.

Dosage and Administration

Oral Administration (Adults):

• Initial dose: 100 mg twice daily, alone or with a diuretic

• Titration: Increase by 100 mg twice daily every 2–3 days based on blood pressure response

• Maintenance: 200–400 mg twice daily; severe hypertension may require 1,200–2,400 mg/day in divided doses

Special Considerations:

• Elderly patients may require lower doses (100–200 mg twice daily) due to slower elimination

• When switching from other antihypertensives, gradually reduce previous therapy while introducing Labegest

Intravenous Administration (Adults):

• Bolus injection: 50 mg IV over at least 1 minute; may repeat every 5 minutes up to 200 mg

• Infusion: Dilute to 1 mg/mL and administer per condition:

  • Pregnancy-induced hypertension: Start at 20 mg/hour, double every 30 minutes as needed (max 160 mg/hour)

  • Hypertensive emergencies post-myocardial infarction: Start at 15 mg/hour, adjust to 120 mg/hour as required

  • General hypertensive crisis: Infuse at ~2 mg/min until desired BP achieved

Pediatric Use: Not established; consult a physician.

Contraindications

• Obstructive airway diseases (e.g., asthma)

• Second- or third-degree heart block

• Cardiogenic shock

• Severe or prolonged hypotension

• Uncompensated heart failure

• Severe bradycardia

Side Effects

Common adverse effects include:

• Postural hypotension

• Tiredness, dizziness, headache

• Nausea, vomiting, epigastric pain

• Liver enzyme abnormalities

• Rare: rashes, scalp tingling, difficulty in micturition

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• May mask symptoms of hypoglycemia in diabetic patients

• Avoid abrupt withdrawal to prevent exacerbation of angina

• Use caution in patients with hepatic impairment, elderly, pregnancy, or lactation

• Monitor carefully during major surgery or when used with anesthesia

Drug Interactions

• Additive hypotensive effects with nitroglycerin, calcium channel blockers

• Synergistic hypotensive effect with halothane

• Altered bioavailability with cimetidine (increased) or glutethimide (decreased)

• Increased tremor risk with tricyclic antidepressants

Pregnancy and Lactation

• Pregnancy Category C: Use only if benefits outweigh risks

• Labetalol crosses into breast milk in very small amounts; caution advised for nursing infants

Storage Conditions

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.

Mode of Action

Labetalol blocks α1- and β-adrenergic receptors, reducing vascular resistance, heart rate, and cardiac output. This dual action lowers blood pressure effectively while minimizing reflex tachycardia, making it suitable for chronic and acute hypertension management.