Intobac 0.3% is a topical ophthalmic antibacterial preparation designed for the treatment of external eye infections caused by susceptible bacteria. Available as both eye drops and eye ointment, Intobac 0.3% helps eliminate bacterial pathogens by interfering with protein synthesis, thereby restoring ocular health and preventing the spread of infection. Proper monitoring of bacterial response is recommended during therapy to ensure efficacy and prevent resistance.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Ophthalmic antibacterial drugs

Composition

Each milliliter of Intobac 0.3% contains:

• Tobramycin 0.3% w/v

Indications

Intobac 0.3% is indicated for the treatment of:

• External infections of the eye, including conjunctivitis and keratitis

• Infections of the ocular adnexa, such as eyelid or periocular bacterial infections

The medication should be used only when caused by bacteria susceptible to Tobramycin, and response should be monitored throughout therapy.

Pharmacology

Intobac 0.3% is an aminoglycoside antibiotic that inhibits bacterial protein synthesis. It binds to both the 30S and 50S ribosomal subunits, disrupting the translation process and producing defective bacterial cell membranes. This bactericidal action leads to the elimination of susceptible organisms, resolving infection and inflammation in the affected eye.

Dosage and Administration

Eye Drops:

• Mild to moderate infections: 1 drop in the affected eye(s) every 4 hours

• Severe infections: 1 drop in the affected eye(s) every hour until improvement, then gradually reduce dosage before discontinuation

Eye Ointment:

• Mild to moderate infections: Apply a thin layer into the conjunctival sac 2–3 times daily

• Severe infections: Apply 3–4 times daily until improvement, then taper the dosage prior to discontinuation

For both forms, patients should follow the prescribed regimen and avoid skipping doses to ensure effective bacterial eradication.

Contraindications

• Known hypersensitivity to Tobramycin or any component of the formulation

• Patients with history of hypersensitivity to other aminoglycosides due to potential cross-reactivity

Side Effects

• Localized ocular toxicity (rare, <3% of patients)

• Hypersensitivity reactions such as:

  • Lid itching or swelling

  • Conjunctival erythema

Most side effects are mild and resolve upon discontinuation of therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• Specific drug interaction studies for Intobac 0.3% ophthalmic preparations have not been established

• Use with caution when combining with other topical ophthalmic medications, unless directed by a physician

Precautions and Warnings

• Avoid prolonged use to prevent overgrowth of non-susceptible organisms, including fungi

• Do not touch the dropper or ointment tip to any surface, including eyes or hands, to maintain sterility

• Avoid wearing contact lenses during treatment unless directed by a doctor; wait at least 15 minutes after application before reinsertion

• Use caution when driving or operating machinery, as blurred vision may occur

• Discontinue therapy and seek alternative treatment if super-infection develops

Pregnancy and Lactation

• Pregnancy: Use only if clearly indicated

• Lactation: Exercise caution; evaluate the need to discontinue nursing or the drug depending on maternal benefit versus risk to the infant

Storage Conditions

• Store in a cool, dry place, away from direct light

• Keep out of reach of children.