Infovir Tablet 10 mg contains Adefovir Dipivoxil, a potent antiviral agent used for the treatment of chronic hepatitis B virus (HBV) infection in adults. This medication is especially beneficial for patients with evidence of active viral replication and elevated liver enzymes. Adefovir Dipivoxil belongs to the class of nucleotide analog reverse transcriptase inhibitors, which act to suppress viral replication and reduce liver inflammation, thereby helping to prevent the progression of liver disease.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Antiviral – Nucleotide Analog Reverse Transcriptase Inhibitor

Pharmacology

Adefovir Dipivoxil is a prodrug that, upon oral administration, is rapidly converted in the body to Adefovir, the active form. Adefovir selectively inhibits hepatitis B virus DNA polymerase, an enzyme essential for viral replication. By acting as a chain terminator during viral DNA synthesis, it prevents HBV from multiplying, thereby reducing viral load in the liver and bloodstream.

Adefovir demonstrates activity against both wild-type and lamivudine-resistant HBV strains. The medication exhibits low protein binding, is primarily excreted unchanged via the kidneys, and has a long intracellular half-life, allowing for once-daily dosing.

Indications

Infovir Tablet 10 mg is indicated for:

• Chronic hepatitis B virus (HBV) infection in adults with evidence of active viral replication

• Patients with elevated alanine aminotransferase (ALT) levels and liver inflammation due to HBV

• Treatment of patients with compensated or decompensated liver disease caused by chronic HBV infection

Dosage and Administration

• Adults: 10 mg orally once daily, with or without food

• The treatment duration depends on the patient’s virologic response and physician assessment

• Dose adjustment is required in patients with renal impairment

Administration Note:
Tablets should be swallowed whole with water and taken consistently at the same time each day to maintain stable drug levels.

Drug Interactions

• Caution is advised with nephrotoxic agents, as combined use may increase the risk of kidney toxicity

• Co-administration with other antivirals should be carefully monitored to avoid additive adverse effects

• Regular monitoring of renal function is recommended during concurrent therapy

Contraindications

• Known hypersensitivity to Adefovir Dipivoxil or any of the tablet excipients

• Severe renal impairment without dose adjustment

Side Effects

Common side effects may include:

• Headache, dizziness, fatigue

• Gastrointestinal disturbances such as nausea, vomiting, and abdominal pain

• Mild elevations in liver enzymes

• Rarely, renal toxicity, lactic acidosis, and hepatomegaly with steatosis may occur

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Monitor renal function regularly during therapy, especially in patients with pre-existing kidney disease

• Long-term use may lead to the development of drug-resistant HBV strains; periodic virologic monitoring is recommended

• Use with caution in patients with decompensated liver disease

Pregnancy and Lactation

Infovir Tablet 10 mg is classified as Pregnancy Category C. There are no adequate, well-controlled studies in pregnant women. It should only be used during pregnancy if the potential benefit outweighs the risk. It is not recommended for use during breastfeeding due to potential excretion in human milk.

Storage Conditions

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.