Informet LA Tablet 1000 mg is a high-strength, long-acting oral antidiabetic medication containing metformin hydrochloride in an extended-release formulation. It is designed for patients with type 2 diabetes mellitus who require enhanced and sustained glycemic control. By releasing metformin gradually over an extended period, Informet LA helps maintain stable blood glucose levels throughout the day while improving gastrointestinal tolerability. This formulation supports convenient once-daily dosing and is suitable for long-term diabetes management when used alongside diet and lifestyle modification.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active ingredient: Metformin Hydrochloride 1000 mg

• Dosage form: Long-acting / extended-release tablet

• Route of administration: Oral

Therapeutic Class

• Biguanide antidiabetic agent

Mechanism of Action

Metformin acts by reducing hepatic glucose production through inhibition of gluconeogenesis in the liver. It also enhances insulin sensitivity in peripheral tissues, particularly skeletal muscle, leading to increased glucose uptake and utilization. Additionally, it decreases intestinal absorption of glucose. The long-acting formulation of Informet LA Tablet 1000 mg ensures gradual release of metformin, resulting in consistent plasma concentrations, prolonged therapeutic effect, and reduced peak-related gastrointestinal side effects commonly associated with immediate-release formulations.

Indications

Informet LA Tablet 1000 mg is indicated for:

• Management of type 2 diabetes mellitus in adults

• Patients requiring higher doses of metformin for effective glycemic control

• Use as monotherapy or in combination with other oral antidiabetic agents or insulin

• Glycemic control when diet and exercise alone are insufficient

Key Benefits

• High-strength formulation for improved glycemic control

• Sustained 24-hour blood glucose management with once-daily dosing

• Improved gastrointestinal tolerability compared to immediate-release metformin

• Does not cause weight gain and has a low risk of hypoglycemia when used alone

• Suitable for long-term diabetes therapy

Dosage & Administration

• Dosage should be individualized based on patient response and tolerability.

• Typically taken once daily with the evening meal or as prescribed by a physician.

• Tablets should be swallowed whole and must not be crushed, chewed, or broken.

• Dose escalation should be gradual to minimize gastrointestinal side effects.

• Regular monitoring of blood glucose levels and renal function is recommended.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions & Warnings

• Use with caution in patients with renal or hepatic impairment.

• Renal function should be evaluated before starting treatment and periodically thereafter.

• Temporary discontinuation may be required before major surgery or imaging procedures involving iodinated contrast agents.

• Contraindicated in patients with severe renal dysfunction, metabolic acidosis, or conditions associated with tissue hypoxia.

• Patients should inform their healthcare provider of all concomitant medications.

Possible Side Effects

Common side effects include nausea, diarrhea, abdominal discomfort, and bloating, particularly during treatment initiation. These effects are usually mild and less frequent with the extended-release formulation. Rarely, lactic acidosis may occur, especially in patients with significant renal impairment.

Storage

• Store in a cool, dry place away from direct sunlight and moisture.

• Keep out of reach of children.

Conclusion

Informet LA Tablet 1000 mg (Metformin Hydrochloride) provides effective, sustained glycemic control with the convenience of once-daily dosing and improved tolerability. Its high-strength, long-acting formulation makes it an excellent option for patients requiring enhanced blood glucose management in type 2 diabetes mellitus.