Hypnofast 7.5 mg Tablet is a benzodiazepine sedative and hypnotic containing Midazolam, designed for the short-term management of insomnia and for sedation prior to surgical or diagnostic procedures. It acts on the central nervous system to produce rapid sedation, anxiolysis, muscle relaxation, and amnesia, helping patients relax before medical interventions or achieve restful sleep. Hypnofast is ideal for adult and elderly patients requiring a controlled, short-term sedative.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Hypnofast 7.5 mg is indicated for:

• Short-term treatment of insomnia where difficulty in falling or maintaining sleep occurs

• Premedication before surgery or diagnostic procedures to induce sedation, reduce anxiety, and promote patient comfort

It is recommended for use under medical supervision for limited durations, typically no longer than 2 weeks, except in special circumstances where the physician extends therapy.

Therapeutic Class

• Benzodiazepine Hypnotics

• Benzodiazepine Sedatives

Pharmacology

Midazolam binds to benzodiazepine receptors on GABA-A neurons in the central nervous system, including the limbic system and reticular formation. By enhancing the inhibitory effect of gamma-aminobutyric acid (GABA):

• Neuronal membranes become hyperpolarized, reducing excitability

• Sedation, hypnosis, muscle relaxation, and anxiolysis are achieved

• Produces amnesic effects, making it useful in pre-procedural sedation

The pharmacological action is dose-dependent, and its short half-life allows rapid onset and recovery, minimizing prolonged sedation.

Dosage and Administration

Oral administration:

• Adults: 7.5–15 mg at bedtime for insomnia

• Elderly or debilitated patients: 7.5 mg at bedtime

• Premedication: 7.5–15 mg, 30–60 minutes before procedure

Intravenous (IV) administration:

• Endoscopic/Cardiovascular procedures: Adults 2.5 mg; elderly or debilitated 1–1.5 mg

• Induction of anesthesia: Adults 10–15 mg; children 0.15–0.20 mg/kg

• Intravenous doses should be administered very slowly, with continuous monitoring

Intramuscular (IM) administration:

• Adults: 0.07–0.1 mg/kg (usually 5 mg)

• Children: 0.15–0.20 mg/kg

• Elderly/debilitated: 0.025–0.05 mg/kg

Rectal administration (children): 0.35–0.45 mg/kg, 20–30 minutes before induction of anesthesia

Drug Interactions

• Enhances CNS depression with neuroleptics, antidepressants, analgesics, antihistamines, and other sedatives

• Additive sedative effects require dose adjustments in polypharmacy

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Severe respiratory insufficiency

• Severe hepatic insufficiency

• Sleep apnea syndrome

• Myasthenia gravis

• Hypersensitivity to benzodiazepines or any component

Side Effects

• Daytime drowsiness, confusion, fatigue, headache, and muscle weakness

• IV or IM administration: respiratory depression, apnea, blood pressure fluctuations

• Rarely: paradoxical reactions such as agitation or irritability

Precautions and Warnings

• Monitor respiration and cardiovascular status during administration

• Avoid long-term use to prevent dependence and tolerance

• Adjust doses in elderly or debilitated patients

• Flumazenil may be used as an antidote in case of overdose

Pregnancy and Lactation

• Avoid during pregnancy unless no safer alternative is available

• Not recommended for breastfeeding mothers, as Midazolam passes into breast milk

Storage Conditions

• Store in a cool, dry place protected from light and moisture

• Keep out of reach of children.