Gynastin Vaginal Suppository is a multi-ingredient antimicrobial formulation designed for the treatment and prevention of vaginal infections caused by bacteria, fungi, and protozoa. Each suppository contains a combination of Metronidazole, Neomycin Sulphate, Polymyxin B, and Nystatin, offering broad-spectrum activity against a wide range of pathogens.

This vaginal suppository provides targeted therapy by delivering active ingredients directly to the site of infection, ensuring rapid action, minimizing systemic side effects, and promoting effective symptom relief. Gynastin is commonly used for bacterial vaginosis, candidiasis, mixed infections, and other vaginal infections presenting with discharge, itching, irritation, or odor.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Metronidazole – effective against anaerobic bacteria and protozoa

• Neomycin Sulphate – broad-spectrum antibiotic against Gram-negative and some Gram-positive bacteria

• Polymyxin B – targets Gram-negative bacteria to enhance antibacterial effect

• Nystatin – antifungal agent effective against Candida species

Mechanism of Action

Gynastin Vaginal Suppository works through the combined action of its active ingredients:

• Metronidazole: Disrupts DNA synthesis in anaerobic bacteria and protozoa, inhibiting replication and leading to cell death.

• Neomycin Sulphate: Binds to bacterial ribosomes, interfering with protein synthesis and causing bacterial cell death.

• Polymyxin B: Alters the bacterial cell membrane of Gram-negative bacteria, leading to leakage of cellular contents and bacterial death.

• Nystatin: Binds to ergosterol in fungal cell membranes, creating pores that disrupt cell integrity, leading to fungal cell death.

This combination ensures comprehensive treatment of mixed infections involving bacteria and fungi.

Indications

Gynastin Vaginal Suppository is indicated for:

• Bacterial vaginosis and mixed vaginal infections

• Vaginal candidiasis and fungal infections

• Trichomoniasis caused by protozoal pathogens

• Symptomatic relief of vaginal itching, irritation, discharge, and odor

• Adjunct therapy following gynecological procedures to prevent infection

It is particularly effective in cases where a single antimicrobial agent may not suffice due to mixed infections.

Dosage and Administration

• Insert 1 suppository into the vagina once daily at bedtime, or as directed by a healthcare professional.

• For best results, the patient should lie down for a few minutes after insertion to allow the suppository to dissolve.

• Maintain regular treatment for the full prescribed course, even if symptoms improve early.

• Avoid sexual intercourse during treatment unless advised otherwise by a physician.

Benefits

• Provides broad-spectrum antimicrobial coverage against bacteria, fungi, and protozoa

• Delivers targeted therapy directly to the site of infection for rapid relief

• Reduces vaginal discharge, odor, itching, and irritation

• Helps restore vaginal health and prevent recurrent infections

• Convenient vaginal suppository form ensures ease of use

Possible Side Effects

Gynastin Vaginal Suppository is generally well-tolerated. Possible side effects may include:

• Mild local irritation or burning sensation

• Vaginal dryness or temporary discomfort

• Rare allergic reactions such as rash or swelling

Seek immediate medical attention if severe allergic reactions or persistent irritation occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Consult a healthcare provider before use during pregnancy or breastfeeding

• Not recommended for patients with known hypersensitivity to any of the active ingredients

• Avoid concurrent use of other vaginal products unless advised by a physician

• Maintain good hygiene during treatment to enhance effectiveness

Storage

• Store below 30°C in a cool, dry place

• Protect from light and moisture

• Keep out of reach of children.