Foly Injection 10 mg/ml contains Folinic Acid, also known as Leucovorin, a biologically active form of folate (Vitamin B9). Unlike regular folic acid, folinic acid does not require conversion by the enzyme dihydrofolate reductase to become active. It is immediately available for DNA synthesis, repair, and cellular growth, making it an essential adjunct in certain medical treatments, especially in oncology and hematology.

Foly Injection is commonly used in situations where rapid and precise folate supplementation is required, such as in patients receiving Methotrexate chemotherapy, where it serves as a “rescue” therapy to reduce toxicity. It is also used in combination with 5-Fluorouracil to enhance anti-cancer effects and in the treatment of severe folate deficiency or megaloblastic anemia when oral administration is not feasible.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Foly Injection 10 mg/ml is indicated for:

• Methotrexate rescue therapy to prevent toxicity in cancer treatment

• Enhancing the effectiveness of 5-Fluorouracil chemotherapy in solid tumors

• Treatment of severe folate deficiency where oral administration is not practical

• Management of megaloblastic anemia due to folate deficiency

• Supportive therapy in metabolic disorders affecting folate utilization

• Prevention of folate-related complications in high-risk patients under medical supervision

This injectable form ensures rapid availability of folate, particularly in critically ill patients or when oral therapy is not suitable.

Dosage and Administration

The dosage of Foly Injection depends on the condition being treated, patient weight, and the treatment protocol:

• Methotrexate rescue therapy: Dosage and timing depend on the Methotrexate regimen; typically administered intravenously shortly after chemotherapy

• Severe folate deficiency or anemia: Dosage is determined by the physician based on patient needs

• Enhancement of 5-Fluorouracil therapy: Administered as part of a combination chemotherapy regimen

Administration instructions:

• Administered intravenously or intramuscularly by a trained healthcare professional

• Ensure correct dilution and dosage according to medical guidelines

• Monitor the patient during administration for any adverse reactions

• Adjust dosage based on response and laboratory results, including blood counts and folate levels

Benefits

• Provides immediate, active folate for rapid therapeutic effect

• Prevents and treats folate deficiency and related anemia

• Reduces toxic effects of Methotrexate during chemotherapy

• Enhances the efficacy of 5-Fluorouracil in cancer treatment

• Supports DNA synthesis, cell growth, and repair, especially in rapidly dividing cells

Side Effects

Foly Injection 10 mg/ml is generally well tolerated. Mild side effects may include:

• Redness or pain at the injection site

• Nausea or mild gastrointestinal discomfort

• Fatigue or mild headache

Rare but serious side effects may include allergic reactions, severe hypotension, or anaphylaxis. Immediate medical attention should be sought if symptoms such as rash, swelling, breathing difficulty, or chest discomfort occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Administer only under medical supervision

• Use cautiously in patients with kidney or liver impairment

• Inform the healthcare provider of all medications being taken to avoid interactions

• Not recommended for self-administration

• Monitor blood counts and clinical response during prolonged therapy

Storage

Store below 30°C in a dry, light-protected place. Keep out of reach of children. Inspect vials for particulate matter or discoloration before use; do not use if compromised.

Foly Injection 10 mg/ml (Folinic Acid) is a vital injectable therapy for rapid folate supplementation, chemotherapy rescue, and treatment of folate deficiency. It ensures effective cellular support, reduces drug toxicity, and improves patient outcomes under proper medical supervision.