Flurazine Tablet 1 mg contains Trifluoperazine, a typical antipsychotic belonging to the phenothiazine group. It is primarily indicated for the management of psychotic disorders and for the short-term treatment of severe anxiety. By acting on specific neurotransmitter pathways in the brain, Flurazine Tablet 1 mg helps control symptoms such as agitation, hallucinations, delusions, and severe emotional disturbances, thereby supporting better mental stability and daily functioning.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Flurazine Tablet 1 mg is indicated for:

• Treatment of schizophrenia and other psychotic disorders

• Short-term management of severe anxiety unresponsive to conventional therapy

• Control of agitation and behavioral disturbances associated with psychiatric conditions

Therapeutic Class

Typical Antipsychotic / Phenothiazine Derivative

Pharmacology

Trifluoperazine exerts its therapeutic effects primarily by blocking dopamine (D2) receptors in the central nervous system, particularly in the mesolimbic pathway. This dopamine antagonism helps reduce positive symptoms of psychosis such as hallucinations and delusions. Trifluoperazine also has antiemetic and sedative properties due to its effects on the chemoreceptor trigger zone and other central pathways. At lower doses, it may provide anxiolytic benefits, while higher doses are used in the treatment of psychotic disorders.

Dosage and Administration

• Psychotic Disorders: Initial doses are usually low and gradually increased based on patient response and tolerance

• Anxiety: Typically administered in small doses for short-term use

• Elderly: Lower initial doses are recommended due to increased sensitivity to side effects

• Pediatric: Use only under specialist supervision

Dosage should always be individualized and adjusted by a qualified healthcare professional.

Drug Interactions

Flurazine Tablet 1 mg may enhance the sedative effects of alcohol, opioids, benzodiazepines, and other central nervous system depressants. Concomitant use with anticholinergic drugs may increase anticholinergic side effects. Caution is advised when used with antihypertensive agents, as trifluoperazine may potentiate their effects. Use with other dopamine antagonists may increase the risk of extrapyramidal symptoms.

Contraindications

Flurazine Tablet 1 mg is contraindicated in patients with:

• Known hypersensitivity to trifluoperazine or other phenothiazines

• Severe central nervous system depression

• Coma or marked hypotensive states

• History of blood dyscrasias

Side Effects

Common adverse effects include:

• Drowsiness and sedation

• Dizziness

• Dry mouth and constipation

• Extrapyramidal symptoms such as tremor, rigidity, and restlessness

Long-term or high-dose therapy may be associated with tardive dyskinesia and other movement disorders.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pregnancy and Lactation

Flurazine Tablet 1 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Trifluoperazine may be excreted in breast milk; therefore, caution is advised when administered to nursing mothers.

Precautions and Warnings

Patients receiving Flurazine Tablet 1 mg should be monitored for signs of extrapyramidal reactions, neuroleptic malignant syndrome, and blood dyscrasias. Caution is required in elderly patients and those with cardiovascular disease, liver impairment, or a history of seizures.

Use in Special Populations

• Elderly: Increased risk of sedation and movement disorders; dose reduction is recommended

• Hepatic Impairment: Use with caution and monitor liver function regularly.