Florium 5 mg Tablet is a calcium channel antagonist primarily used for the prophylaxis of migraine and the management of vestibular and neurological disorders. It is effective in preventing recurrent migraine attacks and is also used in conditions such as vertigo, motion sickness, peripheral vascular disease, and refractory epilepsy. Florium 5 mg works by regulating calcium influx in cells and exhibits mild antihistaminic and sedative properties.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Florium 5 mg is indicated for the following conditions:

• Prophylaxis of classic migraine (with aura) and common migraine (without aura)

• Symptomatic treatment of vestibular vertigo due to functional disorders of the vestibular system

• Peripheral vascular disease (PVD)

• Motion sickness

• Refractory epilepsy resistant to conventional antiepileptic therapy

Therapeutic Class

Miscellaneous Prophylactic Migraine Preparations

Pharmacology

Florium 5 mg is a difluorinated derivative of cinnarizine and acts as a selective calcium channel antagonist. It prevents excessive transmembrane calcium influx, thereby protecting cells from calcium overload without disrupting normal cellular calcium homeostasis. Additionally, Florium 5 mg possesses mild antihistaminic and sedative effects. The drug is highly protein-bound, with approximately 99% binding to plasma proteins.

Dosage & Administration

Migraine Prophylaxis:

• Starting dose:

  • Patients under 65 years: 10 mg at night

  • Patients over 65 years: 5 mg daily

• If depressive, extrapyramidal, or other unacceptable symptoms occur, treatment should be discontinued

• If no significant improvement is observed after 2 months, the patient should be considered a non-responder

Maintenance Therapy:

• Same daily dose administered for 5 days per week with 2 consecutive drug-free days

• Maintenance therapy should be stopped after 6 months, even if effective, and restarted only upon relapse

Peripheral Vascular Disease:

• 10 mg twice daily

• May be increased up to 30 mg per day if required

Vertigo and Motion Sickness:

• Adults: 10–20 mg daily

• Children over 40 kg: 5 mg daily

Epilepsy (Add-on Therapy):

• Adults: 15–20 mg daily

• Children: 5–10 mg daily

Drug Interactions

• Galactorrhoea has been reported in some women taking oral contraceptives during the first two months of therapy

• Hepatic enzyme inducers such as carbamazepine and phenytoin may increase the metabolism of Florium 5 mg, potentially requiring dose adjustment

• Concomitant use with alcohol or CNS depressants may enhance sedative effects

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Florium 5 mg is contraindicated in patients with:

• Known hypersensitivity to the drug

• History of depressive illness

• Pre-existing Parkinson’s disease or other extrapyramidal disorders

Side Effects

Commonly reported side effects include:

• Drowsiness or fatigue

• Weight gain and increased appetite

Adverse effects reported with long-term use include:

• Depression, particularly in patients with a history of depressive illness

• Extrapyramidal symptoms such as bradykinesia, rigidity, tremor, akathisia, and orofacial dyskinesia

• Less frequent effects include nausea, heartburn, gastralgia, insomnia, anxiety, galactorrhoea, dry mouth, muscle pain, and skin rash

Pregnancy & Lactation

The safety of Florium 5 mg during pregnancy and lactation has not been established. Use during these periods is not recommended unless clearly necessary.

Precautions & Warnings

Florium 5 mg may cause drowsiness, which can be aggravated by alcohol or other CNS depressants. Patients should avoid driving or operating machinery if affected. The drug is not intended for aborting acute migraine attacks, and dosage should not be increased during an attack. Long-term use may induce extrapyramidal or depressive symptoms and may unmask Parkinsonism, especially in elderly or predisposed patients. Careful monitoring is advised.

Storage Conditions

Store below 30°C, protected from light and moisture. Keep out of the reach of children.

Mode of Action

Florium 5 mg acts as a selective calcium channel antagonist, reducing excessive calcium entry into cells and preventing cellular calcium overload. It maintains normal calcium balance while providing additional antihistaminic and sedative effects that contribute to its therapeutic benefits.