Flamyd 60 ml is an antiprotozoal and antibacterial agent from the imidazole class. It is primarily indicated for infections caused by anaerobic bacteria and protozoa, including:

1. Prevention of post-operative infections caused by anaerobes such as Bacteroides species and anaerobic streptococci.

2. Treatment of serious anaerobic infections, including:

   • Septicaemia and bacteraemia

   • Peritonitis

   • Brain abscess

   • Pelvic abscess and pelvic cellulitis

   • Post-operative wound infections

3. Urogenital infections:

   • Trichomoniasis

   • Bacterial vaginosis (non-specific vaginitis)

4. Protozoal infections:

   • Amoebiasis (intestinal, extra-intestinal, and asymptomatic cyst carriers)

   • Giardiasis

5. Oral and dental infections:

   • Acute ulcerative gingivitis

   • Acute dental infections due to anaerobic organisms

6. Skin and soft tissue infections:

   • Anaerobically infected leg ulcers and pressure sores

7. Special conditions:

   • Antibiotic-associated pseudomembranous colitis

   • Surgical prophylaxis to prevent anaerobic infections in high-risk surgeries

     রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Amoebicides

• Anti-diarrhoeal antiprotozoal

Pharmacology

Flamyd 60 ml works by metabolic reduction of its 5-nitro group by anaerobic organisms, producing a reactive form that interacts with DNA. This inhibits nucleic acid synthesis, resulting in bactericidal and protozoacidal effects.

Dosage & Administration (Summary)

• Oral Tablets/Suspension: Doses depend on age and condition. Adults: 200–400 mg 2–3 times daily; single doses of 2 g for specific infections. Pediatric doses are weight-based.

• Vaginal Gel: One applicator (~5 g) once or twice daily for 5 days; administer at bedtime if once daily.

• Suppository: Adults: 1 g every 8–12 hours; Children: 500 mg based on age/weight.

• IV Infusion: Adults & children >12 yrs: 500 mg every 8 hours (max 4 g/24h); Children <12 yrs: 7.5 mg/kg every 8 hours.

Drug Interactions

• Disulfiram & Alcohol: Risk of disulfiram-like reaction (flushing, vomiting, tachycardia).

• Warfarin: May potentiate anticoagulant effect; monitor prothrombin time.

• Lithium & Cyclosporin: May increase serum levels, monitor closely.

• Phenytoin/Phenobarbital: May reduce plasma levels of Flamyd.

• 5-Fluorouracil & Busulfan: Altered metabolism may increase toxicity.

Contraindications

• Hypersensitivity to metronidazole or other nitroimidazole derivatives.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

• Common: metallic taste, nausea, vomiting, diarrhea, drowsiness, rashes.

Precautions & Warnings

• Monitor blood counts with prolonged therapy.

• Use caution in hepatic encephalopathy; reduce dose if necessary.

• May darken urine during treatment.

• Patients should avoid alcohol during therapy and for at least 24 hours after the last dose.

Pregnancy & Lactation

• FDA Category B: Use only if clearly needed.

• Excreted in human milk; caution when administered to nursing women.

Pediatric & Geriatric Use

• Pediatric doses are weight-based; adjust in hepatic impairment.

• No routine adjustment required for renal impairment; re-administer post-hemodialysis if needed.

Storage Conditions

• Store below 30°C, protected from light, and out of reach of children.