Fibroz Capsule contains Nintedanib 150 mg, an oral tyrosine kinase inhibitor used for the treatment of idiopathic pulmonary fibrosis (IPF) and other progressive fibrosing interstitial lung diseases. It works by slowing down the progression of lung fibrosis, helping to preserve lung function and improve disease outcomes.

Nintedanib is used under specialist supervision, mainly by pulmonologists, as part of long-term management of chronic fibrotic lung conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Uses

Fibroz Capsule 150 mg is indicated for:

• Idiopathic pulmonary fibrosis (IPF)
• Chronic fibrosing interstitial lung diseases (ILDs) with progressive phenotype
• Systemic sclerosis-associated interstitial lung disease (SSc-ILD)
• Other progressive fibrosing lung diseases as prescribed by a specialist

Mechanism of Action

Nintedanib works by targeting multiple pathways involved in fibrosis development:

• Inhibits tyrosine kinase receptors (VEGFR, FGFR, PDGFR)
• Reduces fibroblast activation and proliferation
• Decreases deposition of fibrotic (scar) tissue in the lungs
• Slows progression of lung tissue damage
• Helps maintain respiratory function over time

Dosage & Administration

• Usual dose: 150 mg twice daily or as prescribed by a physician
• Should be taken with food to minimize gastrointestinal side effects
• Swallow capsules whole with water
• Dose adjustments may be required based on tolerance and liver function
• Regular monitoring of liver enzymes is essential during treatment
• Long-term therapy under specialist care is required

Side Effects

Common side effects may include:

• Diarrhea (most common)
• Nausea and vomiting
• Abdominal pain
• Loss of appetite
• Weight loss
• Elevated liver enzymes
• Fatigue

Serious side effects may include liver injury and increased risk of bleeding in susceptible patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Use only under pulmonologist supervision
• Monitor liver function before and during treatment
• Not recommended during pregnancy due to risk of fetal harm
• Effective contraception is required during therapy
• Use cautiously in patients with bleeding risk or cardiovascular disease
• Dose adjustment may be needed in hepatic impairment
• Inform physician about all ongoing medications

Storage

• Store below 25°C in a cool and dry place
• Protect from moisture and light
• Keep in original packaging
• Keep out of reach of children.