Dynase Nasal Spray is a combination nasal formulation containing Azelastine Hydrochloride (137 mcg) and Fluticasone Propionate (50 mcg) per spray. It is designed for the effective treatment of allergic rhinitis by targeting multiple inflammatory pathways involved in nasal allergy symptoms. The dual-action approach provides rapid symptom relief along with long-term control, making Dynase Nasal Spray suitable for patients with moderate to severe allergic rhinitis.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each spray delivers:

• Azelastine Hydrochloride 137 mcg

• Fluticasone Propionate 50 mcg

Therapeutic Class

Antihistamine (intranasal)
Corticosteroid (intranasal)

Pharmacology

Azelastine Hydrochloride is a second-generation antihistamine that blocks histamine H1 receptors, preventing the effects of histamine released during allergic reactions. It provides rapid relief from symptoms such as sneezing, nasal itching, and rhinorrhea. Azelastine also exhibits mast cell stabilizing and anti-inflammatory properties, which further help control allergic responses.

Fluticasone Propionate is a potent synthetic corticosteroid with strong anti-inflammatory activity. It works by inhibiting multiple inflammatory mediators, including cytokines, prostaglandins, and leukotrienes. Fluticasone reduces nasal mucosal inflammation, edema, and hyperreactivity, leading to sustained symptom relief and improved nasal airflow.

The combination of azelastine and fluticasone offers both immediate and long-term control of allergic rhinitis symptoms with minimal systemic absorption when used intranasally.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Dynase Nasal Spray is indicated for the treatment of:

• Seasonal allergic rhinitis

• Perennial allergic rhinitis

• Nasal congestion

• Sneezing

• Nasal itching

• Runny nose

It is particularly effective in patients who do not achieve adequate symptom control with monotherapy.

Dosage and Administration

• Adults and adolescents: One spray in each nostril twice daily or as directed by a physician.

Before use, the nasal spray should be shaken well and primed if used for the first time or after a prolonged period of non-use. Patients should be advised to gently blow the nose before administration for optimal effectiveness.

Contraindications

Dynase Nasal Spray is contraindicated in patients with:

• Known hypersensitivity to azelastine, fluticasone, or any component of the formulation

Precautions and Warnings

• Prolonged use of intranasal corticosteroids may increase the risk of nasal mucosal irritation or epistaxis.

• Caution is advised in patients with recent nasal surgery, trauma, or infections.

• Use under medical supervision in patients with glaucoma, cataracts, or systemic corticosteroid use.

• Avoid contact with the eyes.

Side Effects

Possible side effects include:

• Nasal irritation or dryness

• Bitter taste

• Sneezing after application

• Headache

• Epistaxis in some patients

Most side effects are mild and self-limiting.

Use in Special Populations

• Pregnancy: Use only if clearly needed and prescribed by a physician.

• Lactation: Caution is advised; medical advice is recommended.

• Pediatric use: Use in children should be based on physician recommendation.

Storage

Store in a cool, dry place below 30°C. Protect from direct sunlight. Keep out of reach of children.