Duracef Capsule 400 mg contains Cefixime Trihydrate, a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It works by inhibiting bacterial cell wall synthesis, leading to the elimination of infection-causing organisms. This high-strength oral capsule is commonly prescribed for moderate to severe infections in adults.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Duracef Capsule 400 mg is indicated for the treatment of:

• Upper respiratory tract infections (pharyngitis, tonsillitis, sinusitis)
• Lower respiratory tract infections (bronchitis, pneumonia)
• Otitis media (middle ear infections)
• Urinary tract infections (UTIs)
• Uncomplicated gonorrhea
• Typhoid fever (caused by susceptible organisms)

Mechanism of Action

Cefixime works by binding to penicillin-binding proteins (PBPs) in bacterial cell walls. This results in:

• Inhibition of cell wall synthesis
• Weakening of bacterial structure
• Bacterial cell death
• Effective eradication of susceptible bacteria

It provides broad-spectrum activity against both gram-positive and gram-negative organisms.

Dosage and Administration

• Usual dose: 400 mg once daily or as directed by a physician
• Can be taken with or without food
• Swallow the capsule whole with water
• Do not crush or chew the capsule
• Complete the full prescribed course even if symptoms improve early

Benefits

• Broad-spectrum antibiotic effective against multiple infections
• Convenient once-daily dosing
• Suitable for moderate to severe bacterial infections
• Helps prevent complications from untreated infections
• Well-established safety and efficacy profile

Possible Side Effects

Common side effects may include:

• Diarrhea
• Nausea
• Abdominal pain
• Headache
• Skin rash

Rare but serious side effects:

• Severe allergic reactions (anaphylaxis)
• Clostridium difficile-associated diarrhea
• Severe skin reactions

Seek immediate medical attention if serious symptoms occur.

Precautions and Warnings

• Not effective against viral infections such as cold or flu
• Use cautiously in patients with penicillin or cephalosporin allergy
• Dose adjustment may be required in renal impairment
• Always complete the full course of therapy
• Use only under medical supervision

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Duracef Capsule may interact with:

• Anticoagulants (e.g., warfarin)
• Probenecid (may increase Cefixime levels)
• Other antibiotics

Inform your healthcare provider about all medications you are taking.

Storage

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.