Doxerol Injection contains Doxercalciferol 2 mcg/ml, a synthetic vitamin D2 analog used to manage secondary hyperparathyroidism in patients with chronic kidney disease (CKD). It helps regulate calcium and phosphorus metabolism by suppressing parathyroid hormone (PTH) secretion, thereby reducing the risk of renal osteodystrophy and maintaining bone health. This injectable formulation ensures precise dosing and rapid absorption in patients requiring parenteral therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Doxercalciferol 2 mcg/ml

Indications

Doxerol Injection is indicated for:

• Secondary hyperparathyroidism in patients with chronic kidney disease (CKD)
• Prevention and management of renal osteodystrophy
• Correction of vitamin D deficiency in patients unable to take oral therapy

Mechanism of Action

Doxercalciferol is a prodrug that is metabolized in the liver to active 1,25-dihydroxyvitamin D2 (calcitriol analog), which:

• Suppresses excessive parathyroid hormone (PTH) secretion
• Enhances intestinal absorption of calcium and phosphorus
• Helps maintain bone mineralization and reduce complications of CKD-related mineral disorders

By regulating PTH levels, it reduces bone pain, fractures, and skeletal deformities in CKD patients.

Dosage and Administration

• Administered intravenously or intramuscularly under medical supervision
• Dose is individualized based on PTH, calcium, and phosphorus levels
• Typically given 2–3 times weekly during hemodialysis sessions
• Monitor serum calcium, phosphorus, and PTH levels regularly
• Adjust dosage gradually to avoid hypercalcemia or hyperphosphatemia

Benefits

• Effectively reduces elevated parathyroid hormone (PTH) levels
• Supports healthy calcium and phosphorus balance
• Prevents complications of renal osteodystrophy
• Suitable for patients who cannot take oral vitamin D analogs
• Easy-to-administer injectable formulation for dialysis patients

Side Effects

Common side effects:

• Mild nausea or vomiting
• Headache or dizziness
• Muscle pain

Serious side effects (rare):

• Hypercalcemia (high calcium levels)
• Hyperphosphatemia (high phosphorus levels)
• Cardiac arrhythmias due to electrolyte imbalance

Seek medical attention immediately if severe symptoms occur.

Precautions

• Monitor calcium, phosphorus, and PTH levels regularly
• Use with caution in patients with hypercalcemia, vitamin D toxicity, or severe cardiovascular disease
• Avoid concomitant use with high-dose calcium supplements unless prescribed
• Adjust dose carefully in patients with liver dysfunction

Contraindications

• Hypercalcemia or vitamin D toxicity
• Hypersensitivity to Doxercalciferol or other vitamin D analogs
• Severe hyperphosphatemia

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May interact with digoxin, thiazide diuretics, or calcium supplements
• Monitor patients for signs of hypercalcemia
• Inform healthcare provider of all concurrent medications

Storage

• Store at 2–8°C
• Protect from light
• Do not freeze
• Keep out of reach of children.