Dormicum 7.5 mg Tablet contains Midazolam, a short-acting benzodiazepine used for the short-term treatment of insomnia and as a sedative premedication before surgical or diagnostic procedures. It produces rapid sedation, muscle relaxation, anxiolysis, and amnesia, making it widely used in both hospital and clinical settings.

Dormicum acts quickly and has a relatively short duration of action, which makes it suitable for temporary sleep disturbances and procedural sedation under medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Benzodiazepine hypnotics

• Benzodiazepine sedatives

Pharmacology

Dormicum 7.5 mg binds selectively to benzodiazepine receptors located on postsynaptic GABA-A receptors in the central nervous system, including the limbic system and reticular formation.

It enhances the inhibitory effect of gamma-aminobutyric acid (GABA) by increasing chloride ion permeability across neuronal membranes. This leads to:

• Hyperpolarization of neurons

• Reduced neuronal excitability

• Sedation and anxiolysis

• Muscle relaxation

• Induction of sleep and amnesia

Its rapid onset and short half-life make it particularly useful for procedural sedation and short-term management of insomnia.

Indications

Dormicum 7.5 mg is indicated for:

• Short-term treatment of insomnia

• Premedication before surgical or diagnostic procedures

• Sedation for endoscopic and cardiovascular procedures

• Induction of anesthesia

Dosage and Administration

Oral Administration

• Adults (Insomnia): 7.5–15 mg daily

• Elderly and debilitated patients: 7.5 mg daily

• Premedication: 7.5–15 mg given 30–60 minutes before procedure

Treatment duration should generally not exceed 2 weeks. Extension beyond this period requires medical supervision.

Intravenous Administration

• Endoscopic/Cardiovascular procedures:

  • Healthy adults: Initial dose 2.5 mg IV

  • Elderly/debilitated: 1–1.5 mg IV

• Induction of anesthesia (Adults): 10–15 mg IV

Intramuscular Administration

• Adults: 0.07–0.1 mg/kg (usual dose ~5 mg)

• Children: 0.15–0.20 mg/kg

• Elderly/debilitated: 0.025–0.05 mg/kg

Rectal Administration (Children)

• 0.35–0.45 mg/kg, 20–30 minutes before induction of anesthesia

IV administration should be given very slowly to minimize respiratory depression risk.

Drug Interactions

Dormicum enhances the sedative effects of:

• Neuroleptics

• Tranquilizers

• Antidepressants

• Hypnotics

• Opioid analgesics

• Anesthetics

• Antipsychotics

• Antiepileptics

• Sedative antihistamines

Concurrent use increases risk of excessive sedation and respiratory depression.

Contraindications

Dormicum 7.5 mg must not be used in patients with:

• Severe respiratory insufficiency

• Severe hepatic insufficiency

• Myasthenia gravis

• Sleep apnea syndrome

• Known hypersensitivity to benzodiazepines

Side Effects

Common side effects at the beginning of therapy may include:

• Daytime drowsiness

• Confusion

• Fatigue

• Headache

• Muscle weakness

Following IV or IM administration, fluctuations in vital signs may occur, including:

• Respiratory depression

• Apnea

• Changes in blood pressure and pulse rate

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Overdose

Severe overdose may cause:

• Coma

• Areflexia

• Cardiorespiratory depression

• Apnea

Effects may be reversed with flumazenil, a benzodiazepine antagonist.

Precautions and Warnings

• Administer IV doses slowly

• Monitor respiratory and cardiovascular function during parenteral use

• Use cautiously in elderly, debilitated, or medically compromised patients

• Risk of dependence with prolonged use

Pregnancy and Lactation

• Should be avoided during pregnancy unless no safer alternative exists

• Benzodiazepines may adversely affect the fetus

• Excreted in breast milk; not recommended during breastfeeding

Storage Conditions

• Store in a cool, dry place

• Protect from light and moisture

• Keep out of reach of children

Mode of Action

Dormicum 7.5 mg potentiates the action of GABA at GABA-A receptors, increasing chloride channel opening frequency and producing sedation, muscle relaxation, anxiolysis, hypnosis, anesthesia, and amnesia.