Daprosis Tablet 2 mg contains Daprodustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) used for the treatment of anemia associated with chronic kidney disease (CKD). It stimulates the body’s natural production of erythropoietin, helping to increase red blood cell production and improve hemoglobin levels. This low-dose formulation is particularly suitable for treatment initiation, dose adjustment, and maintenance therapy under careful medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Daprodustat 2 mg

Mechanism of Action

Daprodustat works by inhibiting hypoxia-inducible factor prolyl hydroxylase enzymes. This leads to stabilization of hypoxia-inducible factor (HIF), which enhances endogenous erythropoietin production in the kidneys and liver. It also improves iron metabolism and utilization, promoting red blood cell formation in the bone marrow and correcting anemia associated with CKD.

Indications

Daprosis Tablet 2 mg is indicated for:

• Anemia in patients with chronic kidney disease (CKD)
• Initiation and maintenance therapy in CKD-related anemia
• Patients undergoing dialysis or not on dialysis (as prescribed)
• Dose titration to achieve and maintain target hemoglobin levels

Dosage and Administration

• Taken orally as directed by a physician
• Dosage is individualized based on hemoglobin levels and patient response
• Can be taken with or without food
• Regular monitoring of hemoglobin is essential
• Dose adjustments should be gradual to avoid excessive increase in hemoglobin

Contraindications

Daprosis Tablet should not be used in:

• Known hypersensitivity to Daprodustat
• Uncontrolled hypertension
• Active malignancy unless prescribed by a specialist
• Pregnancy and breastfeeding unless clearly indicated

Side Effects

Possible side effects include:

• Increased blood pressure
• Headache
• Nausea
• Diarrhea
• Dizziness
• Peripheral edema
• Increased risk of thromboembolic events with excessive hemoglobin rise

Precautions

• Regular monitoring of hemoglobin and blood pressure is required
• Use cautiously in patients with cardiovascular disease
• Ensure adequate iron levels for optimal response
• Dose should be adjusted carefully to avoid complications
• Must be used under medical supervision

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Daprosis Tablet may interact with:

• CYP enzyme inhibitors or inducers
• Iron supplements
• Antihypertensive medications
• Anticoagulants (monitoring recommended)

Storage Conditions

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children.