Cyclotox Injection 200 mg/vial contains Cyclophosphamide, a potent alkylating agent used in chemotherapy for the treatment of various cancers and autoimmune disorders. It works by interfering with the DNA replication process of rapidly dividing cells, thereby inhibiting tumor growth and suppressing abnormal immune activity. This injectable formulation is commonly used in hospital-based oncology and hematology settings.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Cyclophosphamide 200 mg

Mechanism of Action

Cyclophosphamide is a prodrug that is metabolized in the liver into active alkylating metabolites. These metabolites form cross-links with DNA strands, preventing DNA replication and RNA transcription. This results in inhibition of cell division and ultimately leads to cell death, particularly in rapidly dividing cancer cells and immune cells.

Indications

Cyclotox Injection 200 mg/vial is indicated for the treatment of:

• Hodgkin’s lymphoma
• Non-Hodgkin lymphoma
• Acute and chronic leukemias
• Multiple myeloma
• Breast cancer
• Ovarian cancer
• Neuroblastoma
• Retinoblastoma
• Certain autoimmune diseases (e.g., severe lupus, vasculitis) when prescribed

Dosage and Administration

• Administered only under the supervision of a qualified healthcare professional
• Can be given intravenously (IV) or intramuscularly (IM) depending on protocol
• Dosage is based on body surface area, disease type, and treatment regimen
• Adequate hydration is recommended to reduce risk of bladder toxicity
• Dose adjustment is required in hepatic or renal impairment
• Regular monitoring of blood counts is essential during therapy

Contraindications

Cyclotox Injection should not be used in:

• Patients with known hypersensitivity to Cyclophosphamide
• Severe bone marrow suppression
• Active serious infections without appropriate treatment
• Pregnancy and breastfeeding unless clearly necessary under medical supervision

Side Effects

Possible side effects include:

• Nausea and vomiting
• Hair loss (alopecia)
• Bone marrow suppression (leukopenia, thrombocytopenia)
• Hemorrhagic cystitis (blood in urine, bladder irritation)
• Increased risk of infections
• Fatigue and weakness
• Secondary malignancies with long-term use (rare)

Precautions

• Adequate hydration and possible use of protective agents (e.g., mesna) may be required
• Regular blood count and urine monitoring is essential
• Use caution in patients with liver, kidney, or bladder disorders
• Avoid live vaccines during therapy
• Strict medical supervision is required due to toxicity risk

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Cyclotox Injection may interact with:

• Other myelosuppressive drugs (increased toxicity)
• Allopurinol (may increase bone marrow suppression)
• Warfarin (altered anticoagulant effect)
• Drugs affecting liver enzymes

Storage Conditions

• Store below 25°C in a dry place
• Protect from light and moisture
• Keep out of reach of children
• Use reconstituted solution as per clinical guidelines.