Crisa Ointment 2% w/w contains Crisaborole, a non-steroidal phosphodiesterase-4 (PDE-4) inhibitor used for the treatment of inflammatory skin conditions. It is primarily indicated for mild to moderate atopic dermatitis (eczema), providing targeted relief from inflammation, itching, and redness without the adverse effects associated with corticosteroids. Crisaborole works by reducing the production of pro-inflammatory mediators in the skin, helping restore the skin barrier and improve overall skin health.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Crisaborole 2% w/w

• Dosage Form: Topical ointment

• Route of Administration: External use only

Mechanism of Action

Crisaborole inhibits phosphodiesterase-4 (PDE-4), an enzyme that regulates cyclic AMP (cAMP) levels in inflammatory cells. By inhibiting PDE-4, Crisaborole:

• Increases cAMP levels, which reduces the production of inflammatory cytokines such as TNF-α, IL-2, IL-12, and IFN-γ

• Suppresses skin inflammation and itching associated with eczema

• Supports the restoration of the skin barrier function

• Provides localized anti-inflammatory effects without systemic steroid exposure

This mechanism makes Crisa Ointment a safe and effective alternative to topical corticosteroids, especially for long-term use.

Indications

Crisa Ointment 2% w/w is indicated for:

• Mild to moderate atopic dermatitis (eczema) in adults, adolescents, and children aged 2 years and above

• Relief of itching, redness, and inflammation associated with atopic dermatitis

• Patients requiring long-term topical therapy without the risk of skin thinning or other steroid-related side effects

• Maintenance therapy to prevent flare-ups in chronic eczema

Dosage and Administration

• Apply a thin layer of Crisa Ointment to the affected area twice daily (morning and evening) or as directed by a physician.

• Gently rub the ointment into the skin until fully absorbed.

• Wash hands before and after application unless the hands are being treated.

• Avoid contact with eyes, mouth, or mucous membranes.

• Do not cover treated areas with occlusive dressings unless prescribed by a healthcare professional.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to Crisaborole or any component of the ointment

• Open, infected wounds at the site of application unless specifically advised by a physician

Precautions and Warnings

• For external use only

• Use caution in patients with severe skin infections or immunocompromised conditions

• Avoid excessive application to prevent skin irritation

• Discontinue use if severe local reactions occur, such as burning, stinging, or rash

Possible Side Effects

Crisa Ointment is generally well tolerated. Mild side effects may include:

• Temporary burning or stinging sensation at the application site

• Redness or itching

• Rare allergic reactions such as rash or swelling

Storage

Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

Conclusion

Crisa Ointment 2% w/w provides an effective, non-steroidal option for managing mild to moderate atopic dermatitis. By targeting the underlying inflammation without the risks associated with corticosteroids, it helps relieve itching, redness, and discomfort while supporting long-term skin health. Its safety profile and ease of use make it suitable for both children and adults requiring regular topical therapy.