Creva 10 mg Tablet contains Rosuvastatin, a potent statin used to manage hypercholesterolemia and dyslipidemia, and to reduce the risk of cardiovascular events. It works by lowering elevated levels of low-density lipoprotein cholesterol (LDL-C), total cholesterol, and triglycerides while modestly increasing high-density lipoprotein cholesterol (HDL-C).

High cholesterol is a major risk factor for atherosclerosis, heart attack, and stroke. Creva 10 mg plays a vital role in both lipid management and the primary prevention of cardiovascular disease, especially in high-risk individuals.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Statins

• Other Anti-anginal & Anti-ischaemic drugs

Pharmacology

Creva 10 mg (Rosuvastatin) is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme responsible for converting HMG-CoA to mevalonate, a precursor of cholesterol synthesis in the liver.

It lowers cholesterol through two primary mechanisms:

1. Increases hepatic LDL receptors, enhancing the uptake and breakdown of LDL cholesterol from circulation.

2. Reduces hepatic VLDL production, which decreases the total number of VLDL and LDL particles.

This dual action significantly reduces LDL-C and improves the overall lipid profile, contributing to reduced plaque formation and cardiovascular risk.

Indications

Creva 10 mg is indicated for:

• Heterozygous Familial and Non-familial Hypercholesterolemia

• Homozygous Familial Hypercholesterolemia (HoFH)

• Mixed Dyslipidemia (Fredrickson Type IIa and IIb)

• Primary prevention of cardiovascular disease

Dosage and Administration

• Dose range: 5–40 mg once daily

• Usual starting dose: 5–10 mg once daily

• 40 mg dose reserved for patients not reaching LDL-C goals with 20 mg

• HoFH: Starting dose 20 mg daily

• Pediatric HeFH (8–<10 years): 5–10 mg daily

• Pediatric HeFH (10–17 years): 5–20 mg daily

• Pediatric HoFH (7–17 years): 20 mg daily

Creva 10 mg may be taken with or without food, at any time of the day.

Drug Interactions

Notable interactions include:

• Cyclosporine: Increased rosuvastatin exposure; do not exceed 5 mg daily

• Gemfibrosil: Avoid combination; if necessary, limit to 10 mg daily

• Lopinavir/Ritonavir or Atazanavir/Ritonavir: Limit dose to 10 mg daily

• Coumarin anticoagulants: May prolong INR; monitor closely

• Fibrates and Niacin: Increased risk of skeletal muscle effects

Contraindications

Creva 10 mg is contraindicated in:

• Known hypersensitivity to rosuvastatin or components

• Active liver disease or unexplained persistent elevation of liver enzymes

• Pregnant women or women planning pregnancy

• Nursing mothers

Side Effects

Creva 10 mg is generally well tolerated. Common side effects include:

• Headache

• Myalgia (muscle pain)

• Constipation

• Asthenia (weakness)

• Abdominal pain

• Nausea

Rare but serious effects include myopathy and rhabdomyolysis, especially at higher doses.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Increased risk of skeletal muscle effects in elderly patients (>65 years), those with hypothyroidism, renal impairment, or when used with interacting drugs

• Advise patients to report unexplained muscle pain, tenderness, or weakness

• Monitor liver enzymes before and during treatment

• Discontinue therapy if serious muscle or liver symptoms occur

Pregnancy and Lactation

• Safety in pregnancy is not established; contraindicated during pregnancy

• It is unknown whether rosuvastatin is excreted in human milk

• Breastfeeding should be discontinued if treatment is necessary

Storage Conditions

• Store below 30°C

• Protect from light and moisture

• Keep out of reach of children

Use in Special Populations

• Pediatric safety and efficacy require careful dose adjustment as specified

• Use with caution in elderly and patients with renal impairment.