Combocef Tablet 200 mg + 125 mg is a combination antibiotic containing Cefpodoxime Proxetil, a third-generation cephalosporin, and Clavulanic Acid, a beta-lactamase inhibitor. This combination enhances antibacterial effectiveness by protecting Cefpodoxime from enzymatic degradation, allowing it to act against a broader range of bacteria. It is widely used to treat moderate to severe bacterial infections affecting the respiratory tract, urinary tract, skin, and other body systems.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Combocef Tablet is indicated for the treatment of:

• Upper respiratory tract infections (sinusitis, tonsillitis, pharyngitis)
• Lower respiratory tract infections (bronchitis, pneumonia)
• Urinary tract infections (UTIs)
• Skin and soft tissue infections
• Ear infections (otitis media)
• Other infections caused by susceptible organisms

Mechanism of Action

• Cefpodoxime Proxetil: Inhibits bacterial cell wall synthesis, leading to bacterial cell death.
• Clavulanic Acid: Inhibits beta-lactamase enzymes produced by resistant bacteria, thereby protecting Cefpodoxime and extending its spectrum of activity.

Together, they provide a synergistic antibacterial effect against resistant strains.

Dosage and Administration

• The usual adult dose is one tablet twice daily, or as prescribed by a physician
• Should be taken with food to enhance absorption
• Swallow the tablet whole with water; do not crush or chew
• Complete the full course of therapy even if symptoms improve

Benefits

• Broad-spectrum antibiotic effective against resistant bacteria
• Enhanced efficacy due to beta-lactamase inhibition
• Suitable for a wide range of infections
• Convenient oral dosage form
• Helps reduce treatment failure and recurrence

Side Effects

Common side effects may include:

• Nausea or vomiting
• Diarrhea
• Abdominal pain
• Headache

Rare but serious side effects:

• Severe allergic reactions (rash, swelling, breathing difficulty)
• Antibiotic-associated colitis
• Liver enzyme abnormalities

Seek immediate medical attention if serious side effects occur.

Precautions

• Use with caution in patients with a history of penicillin or cephalosporin allergy
• Adjust dose in patients with renal impairment
• Prolonged use may lead to secondary infections
• Inform your doctor about all other medications being taken

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Pregnancy: Use only if clearly necessary and under medical supervision
• Lactation: Generally considered safe; consult a healthcare provider
• Children: Dose adjustment required based on age and body weight

Storage

• Store below 30°C
• Keep in a dry place, protected from light
• Keep out of reach of children.