Reumafen 400 mg Tablet is a widely used nonsteroidal anti-inflammatory drug (NSAID) containing Ibuprofen, designed to relieve pain, reduce inflammation, and lower fever. It is a preferred choice for patients suffering from musculoskeletal pain, arthritis, dental pain, menstrual discomfort, and other conditions associated with acute or chronic inflammation.

Ibuprofen, the active ingredient, works by inhibiting cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins—chemical messengers that mediate pain, inflammation, and fever. By reducing prostaglandin synthesis, Reumafen alleviates pain and inflammation while improving mobility in affected joints or tissues.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Nonsteroidal Anti-Inflammatory Drug (NSAID)

Pharmacology and Mode of Action

Reumafen 400 mg is a propionic acid derivative NSAID. Its pharmacological actions include:

• Analgesic: Reduces mild to moderate pain by inhibiting pain-inducing prostaglandins

• Anti-inflammatory: Decreases inflammation and swelling in tissues and joints

• Antipyretic: Lowers fever by acting on the hypothalamic thermoregulatory center

Ibuprofen is rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations in 1–2 hours. It is extensively bound to plasma proteins and metabolized in the liver, with metabolites excreted mainly through the kidneys.

Indications

Reumafen 400 mg Tablet is indicated for:

• Rheumatoid arthritis and osteoarthritis: Management of pain, swelling, and stiffness in joints

• Acute musculoskeletal pain: Back pain, sprains, strains, and sports injuries

• Fever: Symptomatic relief of elevated body temperature

• Dysmenorrhea: Relief of menstrual pain

• Dental pain and post-operative pain: Short-term management of mild to moderate pain

Dosage and Administration

• Adults: 1 tablet (400 mg) every 6–8 hours as required; do not exceed 3 tablets (1200 mg) per day unless prescribed

• Elderly: Use the lowest effective dose for the shortest duration to reduce the risk of adverse effects

• Children: Pediatric use should follow age- and weight-specific guidelines (consult a physician)

• Take with food or milk to minimize gastrointestinal irritation

• Swallow tablets whole with a glass of water; do not crush or chew

Drug Interactions

• May interact with anticoagulants (e.g., warfarin), other NSAIDs, antihypertensives, and corticosteroids

• Can reduce the efficacy of diuretics and ACE inhibitors

• Use with caution alongside lithium, methotrexate, or antidiabetic drugs

Contraindications

• Hypersensitivity to ibuprofen or any NSAID

• History of asthma, urticaria, or allergic reactions following NSAID administration

• Active gastrointestinal bleeding or peptic ulcer disease

• Severe renal or hepatic impairment

Side Effects

Common adverse effects may include:

• Nausea, vomiting, diarrhea, dyspepsia, abdominal pain

• Headache, dizziness, or lightheadedness

• Rare but serious: gastrointestinal bleeding, ulceration, kidney dysfunction, or allergic reactions

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions & Warnings

• Avoid prolonged use; use the lowest effective dose for the shortest duration

• Monitor for signs of gastrointestinal bleeding, especially in the elderly or patients on anticoagulants

• Caution in patients with cardiovascular disease, hypertension, or renal impairment

• Pregnancy: Avoid during third trimester; use only if clearly needed in the first and second trimesters

• Lactation: Use with caution; minimal amounts of ibuprofen are excreted in breast milk

Storage Conditions

• Store in a cool, dry place below 25°C

• Protect from light and moisture

• Keep out of reach of children

Reumafen 400 mg Tablet is a safe and effective NSAID for managing pain, inflammation, and fever, providing rapid relief while improving quality of life for patients with musculoskeletal, inflammatory, or febrile conditions.