Cavazide Tablet 75 mg + 12.5 mg (Irbesartan + Hydrochlorothiazide) is a combination prescription medication used for the treatment of high blood pressure (hypertension). It contains two active ingredients: Irbesartan 75 mg, an angiotensin II receptor blocker (ARB), and Hydrochlorothiazide 12.5 mg, a thiazide diuretic (water tablet). This dual combination works together to effectively lower blood pressure and reduce the risk of cardiovascular complications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition and Drug Class

Cavazide combines:

• Irbesartan – An ARB that relaxes blood vessels.

• Hydrochlorothiazide – A diuretic that helps the body eliminate excess salt and water through urine.

This combination is often prescribed when blood pressure is not adequately controlled with a single medication alone.

Indications

Cavazide 75 mg + 12.5 mg is primarily indicated for:

1. Hypertension (High Blood Pressure):
It is used in patients whose blood pressure is not sufficiently controlled by Irbesartan alone. Proper blood pressure management reduces the risk of stroke, heart attack, heart failure, and kidney disease.

The combination therapy provides enhanced blood pressure reduction compared to monotherapy, making it an effective treatment option in many patients.

How It Works

The two components work through different but complementary mechanisms:

Irbesartan blocks angiotensin II type 1 (AT1) receptors. Normally, angiotensin II causes blood vessels to constrict and stimulates aldosterone release, leading to salt and water retention. By blocking this hormone, Irbesartan relaxes blood vessels and lowers blood pressure.

Hydrochlorothiazide acts on the kidneys to increase the excretion of sodium and water. This reduces blood volume, which further lowers blood pressure.

Together, these actions:

• Relax blood vessels

• Reduce excess fluid in the body

• Lower blood pressure more effectively

• Decrease strain on the heart

Dosage and Administration

The usual dose is one tablet once daily, preferably taken at the same time each day. It may be taken with or without food. The 75 mg + 12.5 mg strength is typically used as an initial combination dose or for patients who require mild to moderate blood pressure reduction.

Dose adjustments should be made only under medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Cavazide is generally well tolerated, but possible side effects may include:

• Dizziness

• Fatigue

• Headache

• Increased urination

• Nausea

• Low blood pressure (especially when standing)

Hydrochlorothiazide may cause electrolyte imbalances such as low potassium, low sodium, or increased uric acid levels. Irbesartan may sometimes increase potassium levels. Regular monitoring may be required.

Serious side effects are rare but may include severe allergic reactions, kidney function changes, or significant electrolyte disturbances.

Precautions

• Pregnancy: Not recommended, as Irbesartan may harm the unborn baby.

• Kidney or Liver Disease: Use cautiously with medical supervision.

• Electrolyte Imbalance: Periodic blood tests may be needed.

• Drug Interactions: Inform your doctor if you are taking potassium supplements, lithium, NSAIDs, or other blood pressure medications.