Carnovas HZ Tablet 5 mg+12.5 mg is a fixed-dose combination of Nebivolol and Hydrochlorothiazide, formulated for the effective management of hypertension (high blood pressure). This combination brings together two complementary mechanisms of action to achieve better blood pressure control than monotherapy, particularly in patients who do not respond adequately to a single antihypertensive agent.

Nebivolol is a highly selective beta-1 adrenergic receptor blocker with additional vasodilatory properties. It lowers blood pressure by reducing heart rate, myocardial contractility, and cardiac output, while also promoting nitric oxide–mediated vasodilation. This results in improved blood vessel relaxation and enhanced peripheral circulation.

Hydrochlorothiazide is a thiazide diuretic that works by increasing the excretion of sodium and water through the kidneys. By reducing plasma volume and peripheral resistance, it effectively lowers blood pressure and helps prevent fluid retention. When combined with Nebivolol, Hydrochlorothiazide enhances the overall antihypertensive effect while allowing lower doses of each component.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Provides dual-action blood pressure control

• Combines beta-blockade with diuretic effect

• Improves vascular relaxation and blood flow

• Helps reduce cardiovascular risk associated with hypertension

• Convenient once-daily dosing improves patient compliance

Therapeutic Indications

Carnovas HZ Tablet is indicated for:

• Essential hypertension

• Patients requiring combination therapy for optimal blood pressure control

• Reduction of hypertension-related cardiovascular complications when used as prescribed

This formulation is particularly useful when monotherapy with either agent alone is insufficient.

Dosage and Administration

The usual recommended dose is one tablet once daily, or as directed by a physician. It should be taken at the same time each day, preferably in the morning. The tablet should be swallowed whole with water and may be taken with or without food. Dose adjustments depend on individual patient response and clinical condition.

Safety and Precautions

• Use with caution in patients with renal or hepatic impairment

• Monitor electrolytes regularly due to the diuretic component

• Caution is advised in patients with diabetes, gout, asthma, or conduction disorders

• Abrupt discontinuation should be avoided without medical advice

• Not recommended during pregnancy and breastfeeding unless clearly necessary

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Some patients may experience:

• Dizziness or fatigue

• Headache

• Increased urination, especially at the start of therapy

• Electrolyte imbalance

• Slow heart rate

Most side effects are mild and transient. Persistent or severe symptoms should be reported to a healthcare professional.

Storage Instructions

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.

Conclusion

Carnovas HZ Tablet 5 mg+12.5 mg (Nebivolol + Hydrochlorothiazide) offers an effective and well-balanced combination therapy for hypertension. By addressing blood pressure through complementary mechanisms, it provides reliable control, improved compliance, and long-term cardiovascular protection when used under proper medical supervision.