Azofend 200 mg Tablet is a potent azole antifungal medication specifically designed to treat a wide range of serious fungal infections in adults and adolescents aged 12 years and older. Containing Voriconazole, a triazole antifungal, Azofend 200 mg works by inhibiting fungal cytochrome P450-dependent 14-alpha sterol demethylase, a crucial enzyme in the biosynthesis of ergosterol. Ergosterol is an essential component of the fungal cell membrane; its depletion disrupts cell membrane integrity, resulting in inhibition of fungal growth and eventual cell death.

Azofend is particularly effective against invasive aspergillosis, disseminated candidiasis, candidemia, esophageal candidiasis, and severe infections caused by Fusarium species and Scedosporium apiospermum, including strains resistant or intolerant to alternative antifungal treatments. Its broad-spectrum activity makes it a critical choice in the management of life-threatening fungal infections, particularly in immunocompromised patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Other Antifungal Preparations
Triazole Antifungal

Mechanism of Action

Azofend 200 mg selectively inhibits fungal CYP450 14-alpha sterol demethylase, preventing the conversion of lanosterol to ergosterol. The resulting accumulation of 14-alpha-methyl sterols destabilizes the fungal cell membrane, reducing fungal proliferation. Azofend has greater selectivity for fungal CYP450 enzymes compared to mammalian enzymes, which minimizes systemic toxicity.

Indications

Azofend 200 mg is indicated for the treatment of:

• Invasive Aspergillosis

• Disseminated Candidiasis and Candidemia in skin, abdominal organs, kidneys, bladder wall, and wounds (non-neutropenic)

• Esophageal Candidiasis

• Severe Fusarium infections (Fusarium solani)

• Scedosporium apiospermum infections

• Cases resistant to or intolerant of alternative antifungal treatments

It is recommended for patients aged 12 years and older under strict medical supervision.

Dosage and Administration

Oral Administration:

• Take tablets or suspension at least 1 hour before or 1 hour after meals

• ≥40 kg body weight: Loading dose 400 mg (10 ml) every 12 hours for the first 24 hours; maintenance 200 mg (5 ml) twice daily

• <40 kg body weight: Loading dose 200 mg (5 ml) every 12 hours for 24 hours; maintenance 100 mg (2.5 ml) twice daily

Intravenous Administration:

• Invasive Aspergillosis: Loading 6 mg/kg every 12 hours for 24 hours; maintenance 4 mg/kg every 12 hours

• Candidemia and other deep tissue Candida infections: Loading 6 mg/kg every 12 hours for 24 hours; maintenance 3–4 mg/kg every 12 hours

• Scedosporiosis and Fusariosis: Loading 6 mg/kg every 12 hours for 24 hours; maintenance 4 mg/kg every 12 hours

Duration of therapy depends on clinical and mycological response. Long-term exposure beyond 180 days requires careful benefit-risk assessment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Monitor liver function during prolonged therapy

• Use caution in severe hepatic impairment; adjust maintenance dose as necessary

• Avoid co-administration with drugs causing significant CYP3A4, CYP2C9, and CYP2C19 interactions

• Not recommended for pregnant women unless benefit clearly outweighs risk

• Safety and efficacy in children under 12 years not established

• Prolonged use linked to rare reports of squamous cell carcinoma

Side Effects

Common adverse effects may include:

• Abdominal pain, nausea, diarrhea

• Headache, visual disturbances

• Anemia, chest pain

Serious but rare effects include hepatotoxicity and severe allergic reactions.

Storage

• Store below 25°C in a dry, dark place

• Suspension: refrigerate at 2–8°C

• Keep out of reach of children.