Avloclav Injection is a broad-spectrum antibiotic containing Amoxicillin 500 mg and Clavulanic Acid 100 mg per 10 ml. This combination is effective against beta-lactamase-producing bacteria that are resistant to amoxicillin alone. Amoxicillin works by inhibiting bacterial cell wall synthesis, while Clavulanic Acid prevents the breakdown of amoxicillin by bacterial enzymes, enhancing its antibacterial activity. Avloclav Injection is commonly used for moderate to severe bacterial infections in both hospital and clinical settings.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Amoxicillin: 500 mg – penicillin-class antibiotic that disrupts bacterial cell wall formation
• Clavulanic Acid: 100 mg – beta-lactamase inhibitor that protects amoxicillin from enzymatic degradation

Mechanism of Action

• Amoxicillin: Binds to penicillin-binding proteins in susceptible bacteria, inhibiting cell wall synthesis and causing bacterial death
• Clavulanic Acid: Inhibits beta-lactamase enzymes produced by resistant bacteria
• Provides enhanced antibacterial efficacy against a wide range of Gram-positive and Gram-negative pathogens

Indications

Avloclav Injection is indicated for treatment of:

• Respiratory tract infections: bronchitis, pneumonia, sinusitis
• Ear, nose, and throat infections: tonsillitis, otitis media, pharyngitis
• Urinary tract infections: cystitis, pyelonephritis
• Skin and soft tissue infections: abscesses, cellulitis, wound infections
• Bone and joint infections
• Intra-abdominal infections and other susceptible bacterial infections

Dosage and Administration

• Administer via intravenous (IV) infusion or intramuscular (IM) injection as prescribed
• Typical adult dose: 500 mg + 100 mg every 8–12 hours, depending on severity
• Pediatric dosing is weight-based and determined by a healthcare provider
• Reconstitute using sterile water and follow aseptic technique
• Administer IV infusion over 15–30 minutes to reduce irritation

Benefits

• Effective against resistant and susceptible bacteria
• Treats a wide range of respiratory, urinary, skin, and abdominal infections
• Helps prevent treatment failure due to beta-lactamase-producing bacteria
• Suitable for both hospital and outpatient settings

Possible Side Effects

Common side effects:

• Nausea, vomiting, diarrhea
• Rash or mild itching
• Injection site pain or inflammation

Rare but serious side effects:

• Severe allergic reactions (anaphylaxis, swelling, difficulty breathing)
• Liver enzyme elevation, jaundice
• Clostridium difficile-associated diarrhea

Precautions and Warnings

• Contraindicated in patients with penicillin allergy
• Use cautiously in patients with renal impairment
• Monitor for allergic reactions and severe gastrointestinal symptoms
• Avoid use for viral infections
• Inform the physician about all other medications being taken

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May interact with oral anticoagulants, methotrexate, allopurinol, and other antibiotics
• May reduce the effectiveness of oral contraceptives
• Dose adjustment may be needed in kidney dysfunction

Storage Instructions

• Store at 15–25°C, protected from light
• Reconstituted solution should be used immediately or as per stability guidelines
• Keep out of reach of children
• Maintain sterile conditions during preparation and administration.