Aptin M Tablet 50 mg+850 mg is a combination oral antidiabetic medication containing Vildagliptin 50 mg and Metformin Hydrochloride 850 mg. This dual-action formulation is designed to help manage type 2 diabetes mellitus by improving blood sugar control through complementary mechanisms. It is particularly useful for patients who do not achieve adequate glycemic control with diet, exercise, or monotherapy alone.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredients:
  • Vildagliptin 50 mg (DPP-4 inhibitor)
  • Metformin Hydrochloride 850 mg (biguanide)

Mechanism of Action

• Vildagliptin inhibits the DPP-4 enzyme, increasing the levels of incretin hormones (GLP-1 and GIP), which:
  • Stimulate insulin secretion in response to elevated blood glucose
  • Suppress glucagon secretion during hyperglycemia
• Metformin works by:
  • Reducing hepatic glucose production
  • Increasing insulin sensitivity in peripheral tissues
• The combination effectively lowers both fasting and postprandial blood glucose, providing comprehensive glycemic control.

Indications

Aptin M Tablet 50 mg+850 mg is indicated for:

• Type 2 diabetes mellitus in adults
• Patients not adequately controlled on diet, exercise, and single-agent therapy
• Combination therapy for improved glycemic control with a lower risk of hypoglycemia compared to insulin or sulfonylureas
• Long-term management of hyperglycemia in type 2 diabetes

Dosage and Administration

• Adults: One tablet twice daily or as prescribed by a physician
• Take with meals to minimize gastrointestinal side effects from Metformin
• Swallow the tablet whole with water
• Regular monitoring of blood glucose, kidney, and liver function is recommended
• Dosage adjustments may be needed in patients with renal or hepatic impairment

Benefits

• Combines two complementary mechanisms for better blood sugar control
• Reduces fasting and postprandial hyperglycemia
• Convenient once- or twice-daily oral dosing
• Lower risk of hypoglycemia compared to other antidiabetic regimens
• Supports long-term management of type 2 diabetes with improved adherence

Possible Side Effects

Common side effects:

• Nausea, vomiting, or diarrhea (mostly from Metformin)
• Mild headache or dizziness
• Gastrointestinal discomfort

Serious but rare side effects:

• Lactic acidosis (associated with Metformin, very rare)
• Hypoglycemia (particularly if combined with other antidiabetic drugs)
• Allergic reactions, including rash or swelling
• Liver enzyme elevations

Precautions and Warnings

• Not suitable for type 1 diabetes or diabetic ketoacidosis
• Use cautiously in patients with kidney, liver, or heart disease
• Avoid alcohol during treatment due to increased risk of lactic acidosis
• Inform your doctor of all medications and existing conditions
• Regular monitoring of blood glucose, renal, and hepatic function is recommended

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May interact with other antidiabetic drugs, diuretics, or corticosteroids
• Use caution with medications affecting kidney or liver function
• Some contrast agents for imaging may increase risk of lactic acidosis

Storage Instructions

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children.