Annova Plus Tablet 500 mg+20 mg is a combination medication containing Naproxen Sodium, a non-steroidal anti-inflammatory drug (NSAID), and Esomeprazole Magnesium, a proton pump inhibitor (PPI). This dual-action formulation is designed to provide effective relief from pain and inflammation while protecting the stomach from NSAID-induced irritation and ulcers. It is especially beneficial for patients who require long-term pain management.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Naproxen Sodium 500 mg
• Esomeprazole Magnesium 20 mg

Mechanism of Action

Naproxen Sodium works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the production of prostaglandins responsible for pain and inflammation.

Esomeprazole Magnesium reduces gastric acid secretion by inhibiting the proton pump (H+/K+ ATPase) in the stomach lining. This helps protect the gastrointestinal tract from irritation and ulcer formation associated with NSAID use.

Indications

Annova Plus Tablet is indicated for:

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Chronic musculoskeletal pain
• Patients at risk of gastric ulcers due to long-term NSAID use
• Pain associated with inflammatory conditions

Dosage and Administration

• The usual dose is one tablet once daily or as prescribed by a physician
• Take the tablet at least 30 minutes before meals
• Swallow whole; do not crush or chew
• Follow the prescribed duration strictly

Benefits

• Provides effective and sustained pain relief
• Reduces inflammation in chronic conditions
• Protects the stomach from NSAID-induced ulcers
• Convenient combination therapy improves compliance
• Suitable for long-term use under medical supervision

Possible Side Effects

Common side effects may include:

• Nausea
• Abdominal discomfort
• Headache
• Diarrhea or constipation
• Flatulence

Serious but less common side effects:

• Gastrointestinal bleeding
• Kidney impairment
• Allergic reactions (rash, swelling, breathing difficulty)
• Vitamin B12 deficiency with prolonged use

Seek medical attention if severe symptoms occur.

Precautions and Warnings

• Use cautiously in patients with a history of gastrointestinal disorders
• Monitor kidney function during prolonged therapy
• Long-term use may increase the risk of bone fractures
• Avoid in severe liver or kidney disease unless advised
• Not recommended during late pregnancy
• Inform your doctor about any history of heart disease or ulcers

Drug Interactions

• Increased bleeding risk with anticoagulants (e.g., warfarin)
• Avoid concurrent use with other NSAIDs
• Esomeprazole may affect the absorption of certain drugs
• Use cautiously with antiplatelet agents and corticosteroids

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store below 30°C
• Protect from light and moisture
• Keep out of reach of children

Conclusion

Annova Plus Tablet 500 mg+20 mg (Naproxen Sodium + Esomeprazole Magnesium) is an effective combination therapy for managing pain and inflammation while minimizing gastrointestinal risks. It is particularly suitable for patients requiring long-term NSAID treatment under proper medical supervision.