Folinex Tablet contains Folinic Acid (Leucovorin) 15 mg, an active and biologically usable form of folate. It is used in medical and oncology practice to support normal cellular functions, treat folate deficiency, and reduce toxicity from certain chemotherapy drugs. Because it does not require metabolic activation, it acts more rapidly than standard folic acid.

It is commonly used in cancer treatment protocols and in conditions where folate supplementation is clinically required under medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Uses

Folinex Tablet 15 mg is indicated for:

• Folate deficiency and megaloblastic anemia
• Rescue therapy after low-dose or high-dose methotrexate treatment
• Reduction of toxicity from antifolate drugs
• Combination therapy with 5-fluorouracil (5-FU) in colorectal and other cancers
• Supportive care in chemotherapy regimens
• Conditions requiring enhanced folate supplementation

Mechanism of Action

Folinic Acid works through key biochemical actions:

• Bypasses inhibition of dihydrofolate reductase (DHFR) caused by methotrexate
• Restores folate-dependent DNA and RNA synthesis in healthy cells
• Reduces harmful effects of antifolate chemotherapy agents
• Enhances binding of 5-FU metabolites to thymidylate synthase in cancer cells
• Supports red blood cell formation and cellular repair processes

Dosage & Administration

• Usual dose: 15 mg once daily or as directed by physician
• May be taken with or without food
• Dosage varies depending on indication and treatment protocol
• Must be taken exactly as prescribed in chemotherapy regimens
• Do not self-adjust dose without medical advice
• Regular monitoring may be required during treatment

Side Effects

Folinex Tablet is generally well tolerated. Possible side effects include:

• Nausea
• Abdominal discomfort
• Bloating
• Headache
• Mild allergic reactions (rare)
• Sleep disturbances (uncommon)

Serious adverse effects are rare when used appropriately.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Use only under medical supervision
• Do not substitute for folic acid without physician guidance
• Important timing considerations when used with methotrexate therapy
• Correct vitamin B12 deficiency before long-term use
• Inform physician about all concurrent medications
• Use during pregnancy only if clearly necessary

Storage

• Store below 25°C in a cool and dry place
• Protect from moisture and light
• Keep in original packaging
• Keep out of reach of children
• Do not use after expiry date.