Amotrex Injection 500 mg/100 ml contains Metronidazole, a potent antimicrobial and antiprotozoal agent used for treating serious infections caused by anaerobic bacteria and certain protozoa. This intravenous formulation is indicated for patients who require rapid systemic action or are unable to take oral medications due to severe illness, vomiting, or gastrointestinal complications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Metronidazole 500 mg per 100 ml solution

Mechanism of Action

Metronidazole works by entering bacterial and protozoal cells and disrupting DNA synthesis. This inhibits replication and leads to cell death. Its mechanism is particularly effective against anaerobic bacteria that thrive in low-oxygen environments such as deep tissue, intra-abdominal, and gynecological infections.

Indications

Amotrex Injection is indicated for:

• Severe anaerobic bacterial infections
• Intra-abdominal infections such as peritonitis and abscesses
• Gynecological infections, including pelvic inflammatory disease
• Septicemia caused by susceptible organisms
• Bone and soft tissue infections
• Pre- and post-operative prophylaxis in certain surgeries
• Protozoal infections when oral therapy is not feasible

Dosage and Administration

• Administered intravenously by a healthcare professional.
• Typical adult dose: 500 mg every 6–8 hours, depending on infection severity.
• Infuse over 30–60 minutes to minimize adverse reactions.
• Dose adjustments may be required in patients with liver impairment.
• Continuous monitoring may be necessary in critically ill patients.

Benefits

• Provides rapid systemic action for severe infections
• Effective against anaerobic bacteria and protozoal pathogens
• Useful in patients who cannot take oral medication
• Supports faster recovery and prevents complications
• Convenient premixed IV formulation for hospital use

Possible Side Effects

Common side effects may include:

• Nausea and vomiting
• Abdominal discomfort
• Headache
• Metallic taste

Less common but serious side effects:

• Allergic reactions (rash, itching, swelling)
• Neurological symptoms (confusion, seizures, neuropathy)
• Blood abnormalities (rare)

Precautions and Warnings

• Use cautiously in patients with liver disease, kidney impairment, or neurological disorders.
• Avoid alcohol during treatment and for at least 48 hours after administration.
• Monitor for signs of allergic reactions and severe adverse effects.
• Not recommended for use during the first trimester of pregnancy unless necessary.
• Inform healthcare providers of all concurrent medications to avoid interactions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Amotrex Injection may interact with:

• Warfarin (increased bleeding risk)
• Lithium
• Certain antiepileptic drugs
• Alcohol (may cause disulfiram-like reaction)

Storage Instructions

• Store below 30°C in a cool, dry place
• Protect from light
• Do not freeze
• Keep out of reach of children.