Ulticort Ointment 0.05% contains Halobetasol Propionate, a highly potent topical corticosteroid used to manage various inflammatory and pruritic skin disorders. This ointment is specifically formulated to provide rapid relief from redness, itching, swelling, and discomfort associated with dermatological conditions such as eczema, psoriasis, lichen planus, and other corticosteroid-responsive dermatoses.

Halobetasol Propionate works by suppressing inflammation and immune responses in the affected skin areas. The ointment base enhances penetration, ensuring maximum efficacy at the site of application. Ulticort Ointment 0.05% is intended for short-term use due to its high potency, providing fast symptomatic relief and improving patients’ quality of life.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Topical Corticosteroid – Super Potent

Indications

Ulticort Ointment 0.05% is indicated for the management of:

• Eczema and dermatitis: Relieves inflammation, redness, and itching in acute and chronic flare-ups

• Psoriasis: Reduces plaque thickness, scaling, and erythema

• Lichen planus: Controls pruritus and inflammatory lesions

• Other corticosteroid-responsive dermatoses: Effective in treating localized inflammatory skin conditions that respond to potent topical steroids

This ointment is especially useful for patients with resistant or severe inflammatory skin disorders that have not adequately responded to lower-potency corticosteroids.

Pharmacology

Halobetasol Propionate is a synthetic corticosteroid with strong anti-inflammatory, antipruritic, and vasoconstrictive properties. Its pharmacological effects are mediated by:

• Inhibition of pro-inflammatory mediators: Halts the release of histamine, prostaglandins, and leukotrienes that trigger inflammation

• Reduction of vascular permeability: Minimizes swelling and redness

• Suppression of immune response: Decreases infiltration of inflammatory cells, reducing pruritus and lesion formation

Absorption and Systemic Effects:

• Following topical application, a small fraction of the drug is absorbed systemically.

• Systemic absorption increases with prolonged use, higher doses, application under occlusion, or on damaged skin.

• Most of the absorbed drug is metabolized in the liver and excreted via urine.

Mode of Action

• Binds to glucocorticoid receptors in skin cells

• Modulates gene expression to reduce inflammatory mediator production

• Provides rapid relief from erythema, swelling, and itching

• Minimizes immune-mediated damage to skin tissue

Dosage and Administration

• Apply a thin layer of Ulticort Ointment 0.05% once or twice daily to the affected area, or as prescribed by a physician

• Gently rub the ointment until fully absorbed

• Use short-term therapy (usually not more than 2 weeks) to avoid adverse effects

• Avoid covering treated areas with occlusive dressings unless directed by a doctor

• Wash hands immediately after application to prevent accidental transfer to eyes or other sensitive areas

Special Considerations:

• Avoid using on broken or infected skin unless combined with appropriate antimicrobial therapy

• Do not use on the face, groin, or underarms for extended periods without medical supervision due to increased risk of adverse effects

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Known hypersensitivity to Halobetasol Propionate or any component of the ointment

• Viral, bacterial, or fungal skin infections unless used in combination with appropriate antimicrobial therapy

• Acne, rosacea, perioral dermatitis, or skin atrophy-prone areas for long-term use

Side Effects

Common adverse effects may include:

• Mild burning, stinging, or itching at the application site

• Skin dryness or irritation

• Redness or contact dermatitis

Less common or prolonged-use effects may include:

• Skin atrophy, thinning, or striae

• Telangiectasia (visible small blood vessels)

• Secondary infections due to immunosuppression of local skin

• HPA axis suppression in rare cases with extensive or prolonged use

Precautions and Warnings

• Limit use to affected areas and shortest duration possible

• Avoid application near eyes or mucous membranes

• Monitor for signs of secondary infection

• Use with caution in elderly patients and children due to increased risk of systemic absorption

Pregnancy and Lactation

• Use only if the potential benefit outweighs the risk

• Systemic absorption is minimal, but caution is advised when applied extensively

• Avoid using on large areas during pregnancy or breastfeeding

Storage Conditions

• Store in a cool, dry place, protected from light

• Keep out of reach of children.