Adafil 10 mg Tablet is a prescription medicine primarily used for the management of erectile dysfunction (ED) in men. It is also effective in relieving the signs and symptoms of benign prostatic hyperplasia (BPH) and in patients who experience both erectile dysfunction and BPH simultaneously. Adafil 10 mg belongs to the therapeutic class of drugs used for erectile dysfunction and works by improving blood flow and relaxing smooth muscles.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Adafil 10 mg is indicated for the treatment of:

• Erectile Dysfunction (ED)

• Benign Prostatic Hyperplasia (BPH)

• Erectile Dysfunction associated with signs and symptoms of Benign Prostatic Hyperplasia

Therapeutic Class

Drugs for Erectile Dysfunction

Pharmacology

Adafil 10 mg contains a selective phosphodiesterase type 5 (PDE5) inhibitor. PDE5 inhibition increases the concentration of cyclic guanosine monophosphate (cGMP) in smooth muscle cells. Elevated cGMP leads to relaxation of smooth muscles and increased blood flow into the corpus cavernosum, resulting in a penile erection during sexual stimulation.

PDE5 is also present in the smooth muscles of the prostate and bladder. Inhibition of PDE5 in these tissues increases cGMP levels, leading to smooth muscle relaxation in the prostate and bladder wall. This relaxation improves blood flow to the urinary tract and helps widen the bladder neck opening, thereby improving urinary symptoms associated with BPH.

Dosage and Administration

Erectile Dysfunction:

• Recommended starting dose: 10 mg

• Dose may be increased to 20 mg or reduced to 5 mg based on patient response and tolerability

• Maximum dosing frequency: once daily

• Effective for up to 36 hours

Benign Prostatic Hyperplasia:

• Recommended dose: 5 mg taken once daily at the same time each day

Combined Erectile Dysfunction and BPH:

• Recommended dose: 5 mg taken once daily at the same time each day

Dosage should always be adjusted according to medical advice.

Drug Interactions

Adafil 10 mg may interact with:

• Nitrates such as nitroglycerin and isosorbide

• Alpha-adrenergic blockers

• Antihypertensive medicines

• Alcohol

• Antacids containing magnesium hydroxide or aluminum hydroxide

• CYP3A4 inhibitors such as ketoconazole, itraconazole, erythromycin, ritonavir

• HIV protease inhibitors

• Rifampin, carbamazepine, phenytoin, phenobarbital

• Grapefruit juice

Concomitant use with these agents may require dose adjustment or careful monitoring.

Contraindications

Adafil 10 mg is contraindicated in:

• Patients using nitrates, as this may cause severe hypotension

• Patients with known hypersensitivity to Adafil 10 mg or any of its components

Side Effects

Common side effects include:

• Headache

• Dyspepsia

• Back pain

• Myalgia

• Nasopharyngitis

• Nasal congestion

Rare but serious side effects may include changes in color vision, sudden vision or hearing loss, Stevens-Johnson syndrome, exfoliative dermatitis, angina, stroke, myocardial infarction, severe hypotension, and tachycardia.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pregnancy and Lactation

Adafil 10 mg is classified as Pregnancy Category B by the USFDA. It should be used during pregnancy only if the potential benefit justifies the possible risk to the fetus. There is no available data regarding its excretion in human breast milk, so caution is advised when administering to nursing women.

Precautions and Warnings

Caution is required in patients with:

• Angina

• Renal or hepatic impairment

• Bleeding disorders

• Concomitant use of nitrates, alpha blockers, alcohol, CYP3A4 inhibitors, or other PDE5 inhibitors

Medical supervision is recommended in these conditions.

Storage Conditions

Store in a dry place, protected from light and heat.
Keep out of reach of children.

Drug Class

Drugs for Erectile Dysfunction

Mode of Action

Adafil 10 mg acts by selectively inhibiting phosphodiesterase type 5 (PDE5), resulting in increased cGMP levels. This leads to smooth muscle relaxation in the penile tissue, prostate, and bladder, improving erectile function and urinary symptoms.