Actifol Tablet 5 mg contains Folinic Acid, a biologically active form of folate (Vitamin B9). Unlike folic acid, folinic acid does not require conversion in the body to become active, making it effective in patients with folate deficiency or impaired folate metabolism.

Actifol 5 mg is commonly used to prevent and treat folate deficiency, support red blood cell production, and reduce the toxic effects of certain chemotherapy drugs. It is also essential for DNA synthesis, cell division, and tissue growth, supporting overall cellular health.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Actifol Tablet 5 mg is indicated for:

• Treatment and prevention of folate deficiency and megaloblastic anemia
• Adjunct therapy in cancer patients receiving methotrexate to prevent toxicity
• Management of homocystinuria and other metabolic disorders
• Supporting pregnancy in high-risk cases to prevent neural tube defects
• Correcting folate deficiency caused by malabsorption syndromes

Mechanism of Action

Folinic Acid acts by:

• Serving as a cofactor in nucleotide synthesis, critical for DNA and RNA formation
• Bypassing the metabolic step required to activate folic acid, providing immediate bioavailable folate
• Counteracting the toxic effects of folate antagonists like methotrexate by restoring folate-dependent metabolic pathways

This mechanism ensures proper red blood cell formation, supports cellular growth, and helps reduce chemotherapy-related side effects.

Dosage and Administration

• Adults: 5–15 mg daily or as prescribed by a physician
• Children: Dose is weight-based; generally 1–2 mg/kg/day, according to medical guidance
• Tablets should be taken orally with water, preferably after meals
• Follow the prescribed regimen exactly to prevent deficiency or overdose
• Adjustments may be necessary for patients with kidney or liver impairment

Side Effects

Common side effects:

• Mild gastrointestinal discomfort, including nausea or abdominal pain
• Flushing or warmth sensation

Rare but serious side effects:

• Allergic reactions such as rash, itching, or swelling
• Hypersensitivity reactions

Seek medical advice if side effects persist or worsen.

Precautions and Warnings

• Use with caution in patients with kidney or liver disease
• Not a substitute for a balanced diet unless prescribed
• Consult a physician if pregnant, planning pregnancy, or breastfeeding
• Regular blood count monitoring may be necessary during prolonged therapy
• Keep out of reach of children

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Actifol Tablet may interact with:

• Methotrexate – used to reduce toxicity; dosing must be carefully timed
• Anticonvulsants (phenytoin, phenobarbital) – may alter folate levels
• Trimethoprim or other folate antagonists – may require dose adjustments

Inform your doctor about all medications being taken.

Storage Instructions

• Store at 20–25°C (room temperature)
• Keep the tablet in its original packaging to protect from moisture and light
• Keep out of reach of children
• Do not use after the expiry date.