Actifol Tablet 15 mg contains Folinic Acid, also known as Leucovorin, a biologically active form of folate (Vitamin B9). Unlike folic acid, folinic acid bypasses metabolic conversion in the body, making it effective in patients who have folate deficiency or impaired folate metabolism.

Actifol is commonly used to support red blood cell production, prevent certain types of anemia, and reduce the toxic effects of specific chemotherapy drugs. It is also essential for DNA synthesis, cell division, and tissue growth, making it a critical supplement in various clinical situations.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Actifol Tablet 15 mg is indicated for:

• Treatment and prevention of folate deficiency and megaloblastic anemia
• Supportive therapy in cancer patients receiving methotrexate to prevent toxicity
• Management of homocystinuria and certain metabolic disorders
• During pregnancy to prevent neural tube defects in high-risk cases
• Support in conditions causing malabsorption of folate

Mechanism of Action

Folinic Acid works by:

• Acting as a cofactor in the synthesis of nucleotides, essential for DNA and RNA production
• Bypassing the metabolic step required to convert folic acid into active forms, providing immediate bioavailable folate
• Counteracting the toxic effects of folate antagonists like methotrexate by restoring folate-dependent metabolic pathways

This mechanism ensures proper red blood cell formation, supports cellular growth, and reduces chemotherapy-related side effects.

Dosage and Administration

• Adults: 15–30 mg daily, as prescribed by the physician
• Children: Dose is weight-based; typically 1–2 mg/kg/day, according to medical guidance
• Tablets should be taken orally with water, preferably after meals
• Follow the prescribed regimen strictly to prevent deficiency or toxicity
• Adjustments may be required for patients with kidney or liver impairment

Side Effects

Common side effects:

• Mild gastrointestinal discomfort, such as nausea, vomiting, or abdominal pain
• Flushing or warmth sensation

Rare but serious side effects:

• Allergic reactions, including rash, itching, or swelling
• Hypersensitivity reactions

Consult a physician if side effects persist or worsen.

Precautions and Warnings

• Use with caution in patients with kidney or liver disease
• Not a substitute for dietary folate intake unless prescribed
• Consult a doctor if pregnant, planning pregnancy, or breastfeeding
• Regular monitoring of blood counts may be necessary during therapy
• Keep out of reach of children

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Actifol may interact with:

• Methotrexate – used to reduce toxicity, must be carefully timed
• Anticonvulsants (phenytoin, phenobarbital) – may alter folate levels
• Trimethoprim or other folate antagonists – may require dose adjustments

Inform your healthcare provider about all medications being taken.

Storage Instructions

• Store at 20–25°C (room temperature)
• Keep the tablet in the original packaging to protect from moisture
• Keep out of reach of children
• Do not use after the expiry date.