Aciphin Injection 2 gm contains Ceftriaxone Sodium, a third-generation cephalosporin antibiotic designed to treat a broad spectrum of bacterial infections. Ceftriaxone acts by inhibiting bacterial cell wall synthesis, causing bacterial cell death. Its potent activity against both Gram-positive and Gram-negative bacteria makes it ideal for treating serious infections of the respiratory tract, urinary tract, skin, bones, joints, and systemic infections.

The 2 gm vial is formulated for intravenous (IV) or intramuscular (IM) use, offering rapid therapeutic effects, high bioavailability, and suitability for severe infections requiring higher doses.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Aciphin Injection 2 gm is indicated for the management of:

• Severe respiratory tract infections such as pneumonia and bronchitis
• Complicated urinary tract infections
• Skin and soft tissue infections
• Bone and joint infections, including osteomyelitis
• Bacterial meningitis
• Septicemia and other systemic bacterial infections
• Sexually transmitted infections like gonorrhea caused by susceptible organisms

Mechanism of Action

Ceftriaxone is a bactericidal antibiotic that:

• Binds to penicillin-binding proteins in the bacterial cell wall
• Inhibits bacterial cell wall synthesis, leading to cell lysis and death
• Exhibits broad-spectrum activity against both aerobic and anaerobic pathogens

This mechanism ensures rapid bacterial clearance and effective infection resolution.

Dosage and Administration

• Adults: 1–4 g daily depending on infection severity, administered as a single daily dose or divided doses.
• Children: Dose calculated according to body weight and clinical condition.
• Route: Administered via IV infusion or IM injection.
  • IM: Reconstitute with a suitable sterile solution.
  • IV: Dilute in 50–100 ml compatible fluid and infuse over 30 minutes.
• Complete the full course of therapy even if symptoms improve to prevent bacterial resistance.

Side Effects

Common side effects:

• Pain, swelling, or redness at the injection site
• Nausea, vomiting, or diarrhea
• Mild skin rash or itching

Rare but serious side effects:

• Severe allergic reactions, including anaphylaxis
• Hematologic abnormalities such as leukopenia or thrombocytopenia
• Liver enzyme elevations or hepatitis
• Clostridium difficile-associated diarrhea

Seek immediate medical attention for severe or persistent symptoms.

Precautions and Warnings

• Use with caution in patients with a history of penicillin or cephalosporin allergy.
• Monitor renal and hepatic function during prolonged therapy.
• Adjust dosage in patients with kidney or liver impairment.
• Not effective against viral infections such as influenza or the common cold.
• Report severe diarrhea, jaundice, or hypersensitivity reactions promptly.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Aciphin Injection may interact with:

• Aminoglycosides – increased risk of nephrotoxicity
• Anticoagulants – may enhance anticoagulant effects
• Live bacterial vaccines – efficacy may be reduced during therapy
• Loop diuretics – may increase risk of kidney impairment

Inform your physician of all medications being taken.

Storage Instructions

• Store at 2–8°C (refrigerated)
• Protect from light and moisture
• Keep the vial tightly closed until use
• Do not freeze
• Keep out of reach of children.