Aciphin Injection 1 gm contains Ceftriaxone Sodium, a third-generation cephalosporin antibiotic that effectively treats a wide range of bacterial infections. Ceftriaxone works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. Its broad-spectrum activity makes it highly effective against Gram-positive and Gram-negative bacteria, offering reliable therapy for respiratory, urinary, skin, bone, joint, and systemic infections.

The 1 gm vial formulation is suitable for intravenous or intramuscular administration, allowing rapid onset of action and high bioavailability, making it ideal for moderate to severe infections in adults and children.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Aciphin Injection 1 gm is indicated for:

• Severe respiratory tract infections including pneumonia and bronchitis
• Urinary tract infections, including complicated infections
• Skin and soft tissue infections
• Bone and joint infections such as osteomyelitis
• Meningitis caused by susceptible bacteria
• Septicemia and other systemic bacterial infections
• Sexually transmitted infections like gonorrhea caused by susceptible strains

Mechanism of Action

Ceftriaxone is a bactericidal antibiotic that:

• Binds to penicillin-binding proteins, inhibiting bacterial cell wall synthesis
• Causes bacterial cell lysis and death
• Exhibits broad-spectrum activity against both aerobic and anaerobic pathogens

By halting bacterial proliferation, Ceftriaxone effectively clears infections and reduces complications.

Dosage and Administration

• Adults: 1–2 g daily depending on infection severity; may be administered as a single daily dose or divided doses.
• Children: Dosage is calculated according to body weight and clinical condition.
• Administration: Intravenous (IV) infusion or intramuscular (IM) injection.
  • For IM injection, reconstitute with a suitable sterile solution.
  • For IV infusion, dilute in 50–100 ml compatible fluid and infuse over 30 minutes.
• Complete the full prescribed course even if symptoms improve to prevent bacterial resistance.

Side Effects

Common side effects:

• Pain, swelling, or redness at the injection site
• Nausea, vomiting, or diarrhea
• Mild skin rash or itching

Rare but serious side effects:

• Severe allergic reactions, including anaphylaxis
• Hematological disorders such as leukopenia, thrombocytopenia
• Liver enzyme elevations or hepatitis
• Clostridium difficile-associated diarrhea

Immediate medical attention is required for severe reactions or persistent symptoms.

Precautions and Warnings

• Use with caution in patients with a history of penicillin or cephalosporin allergy.
• Monitor renal and hepatic function in prolonged therapy.
• Adjust dose in patients with kidney or liver impairment.
• Not effective for viral infections such as influenza or the common cold.
• Report any signs of severe diarrhea, jaundice, or hypersensitivity reactions promptly.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Aciphin Injection may interact with:

• Aminoglycosides – increased risk of nephrotoxicity
• Anticoagulants – enhanced anticoagulant effect
• Live bacterial vaccines – efficacy may be reduced
• Loop diuretics – potential for kidney impairment

Inform your healthcare provider of all medications being taken.

Storage Instructions

• Store at 2–8°C (refrigerated)
• Protect from light and moisture
• Keep the vial tightly closed until use
• Do not freeze
• Keep out of reach of children.