Zepatid Injection 2.5 mg/0.5 ml contains Tirzepatide, a novel dual GIP and GLP-1 receptor agonist used for the management of type 2 diabetes mellitus and chronic weight management in eligible adult patients. It helps improve blood glucose control while also supporting clinically significant weight reduction when combined with diet and exercise.

Tirzepatide works by enhancing insulin secretion, reducing glucagon levels, and improving appetite regulation, making it an effective once-weekly injectable therapy for metabolic control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Uses

Zepatid Injection is indicated for:

• Type 2 diabetes mellitus (as an adjunct to diet and exercise)
• Improvement of glycemic control in adults
• Chronic weight management in overweight or obese patients with associated risk factors (as prescribed by physician)
• Reduction of cardiovascular risk factors associated with obesity and diabetes (as part of comprehensive management)

It is not indicated for type 1 diabetes or diabetic ketoacidosis.

Mechanism of Action

Tirzepatide works through a dual incretin receptor mechanism:

• GIP (Glucose-dependent insulinotropic polypeptide) receptor activation increases insulin secretion and improves metabolic efficiency
• GLP-1 (Glucagon-like peptide-1) receptor activation enhances insulin release, suppresses glucagon secretion, and slows gastric emptying
• Together, these actions improve blood glucose control and reduce appetite, leading to weight reduction

This combined mechanism provides superior glycemic and metabolic benefits compared to single-pathway therapies.

Dosage and Administration

• Administered as a subcutaneous injection once weekly
• Dosage is initiated at a low dose (commonly 2.5 mg) and gradually adjusted by a physician based on response and tolerance
• Injection sites include abdomen, thigh, or upper arm, and should be rotated regularly
• Can be taken with or without meals
• Use exactly as prescribed; do not self-adjust dose
• Missed dose should be taken within the recommended time window or skipped as per medical advice

Possible Side Effects

Common side effects may include:

• Nausea
• Vomiting
• Diarrhea
• Decreased appetite
• Constipation
• Abdominal discomfort

Less common but serious effects may include:

• Pancreatitis
• Gallbladder-related issues
• Hypoglycemia (especially with other antidiabetic drugs)
• Allergic reactions

Medical attention should be sought if severe or persistent symptoms occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Not recommended for type 1 diabetes patients
• Use cautiously in patients with history of pancreatitis
• Monitor blood glucose regularly during therapy
• May affect gastrointestinal motility
• Not recommended during pregnancy or breastfeeding unless advised by physician
• Inform healthcare provider about all concurrent medications

Storage Conditions

• Store in a refrigerator at 2°C to 8°C
• Do not freeze
• Protect from direct light
• Keep in original packaging
• Keep out of reach of children.