Xibrofen 0.09% Ophthalmic Solution is a non-steroidal anti-inflammatory eye preparation used to manage inflammation and relieve ocular pain following cataract surgery. It is formulated to reduce postoperative discomfort and support patient recovery after ocular procedures.

Therapeutic Class

Ophthalmic Non-Steroid Drugs

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Xibrofen 0.09% is indicated for:

• Treatment of postoperative ocular inflammation

• Reduction of eye pain following cataract extraction

It is specifically intended for use after eye surgery to control inflammation mediated by prostaglandins.

Pharmacology

Xibrofen 0.09% contains a nonsteroidal anti-inflammatory drug that works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing prostaglandin synthesis. Prostaglandins play a key role in intraocular inflammation and are associated with vasodilation, increased vascular permeability, leukocyte infiltration, disruption of the blood-aqueous barrier, and elevated intraocular pressure. By suppressing prostaglandin production, Xibrofen helps control inflammation and pain in the operated eye.

Mode of Action

• Inhibits cyclooxygenase-1 and cyclooxygenase-2 enzymes

• Reduces prostaglandin-mediated inflammatory responses

• Decreases ocular pain, redness, and swelling after surgery

Dosage and Administration

Adults:

• Instill 1 drop into the affected eye twice daily

• Treatment should begin 24 hours after surgery

• Continue therapy for 2 weeks

Children:

• Use and dosage must be determined by a physician

Pediatric Use:

• Safety and efficacy in patients below 18 years of age have not been established

Contraindications

Xibrofen 0.09% ophthalmic solution is contraindicated in patients with:

• Known hypersensitivity to bromfenac or any component of the formulation

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

The most commonly reported adverse reactions (2–7% of patients) include:

• Abnormal sensation in the eye

• Conjunctival hyperemia

• Eye irritation, burning, or stinging

• Eye pain or itching

• Eye redness

• Headache

• Iritis

Most reactions are mild to moderate in intensity.

Pregnancy and Lactation

• Pregnancy Category C

• Xibrofen 0.09% should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus

• Caution is advised when administering to nursing mothers

Precautions and Warnings

• Topical NSAIDs may delay or slow corneal healing

• Concomitant use with topical corticosteroids may increase the risk of healing complications

• Use with caution in patients with bleeding tendencies or those receiving anticoagulant therapy

• Contact lenses should not be worn during treatment

• Contains sodium sulfite, which may cause allergic-type reactions, including severe asthma, in susceptible individuals

Storage Conditions

• Store in a cool, dry place away from heat and direct light

• Keep out of the reach of children

• Do not use for more than 4 weeks after opening

Drug Class

Ophthalmic Non-Steroid Drugs.