Vorifast Tablet 100 mg contains Voriconazole, a broad-spectrum triazole antifungal medicine used for the treatment of serious and invasive fungal infections. It is commonly prescribed for conditions such as invasive aspergillosis, severe candidiasis, and other systemic fungal infections, particularly in immunocompromised patients including those undergoing chemotherapy, organ transplantation, or with significant immune suppression.

Voriconazole works by inhibiting the fungal enzyme lanosterol 14-α-demethylase, which is essential for the synthesis of ergosterol. Ergosterol is a vital component of fungal cell membranes. By blocking its formation, Voriconazole disrupts the structure and function of the fungal cell membrane, leading to inhibition of fungal growth and eventual cell death.

Vorifast Tablet 100 mg is often used as part of an initial treatment regimen or as maintenance therapy following intravenous administration. It may also be used for dose adjustments based on patient weight, liver function, and clinical response. Due to its potent antifungal activity, careful medical supervision is required during treatment.

Regular monitoring is essential during therapy, including liver function tests and assessment of clinical response, to ensure safety and effectiveness. The medicine should be used strictly under the guidance of a registered physician.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Voriconazole BP 100 mg

Indications

Vorifast Tablet is indicated for:

• Invasive aspergillosis
• Serious Candida infections
• Esophageal candidiasis
• Scedosporium infections
• Fusarium infections
• Severe systemic fungal infections in immunocompromised patients

How It Works

Voriconazole inhibits lanosterol 14-α-demethylase, blocking ergosterol synthesis in fungal cell membranes. This weakens the membrane structure, inhibits fungal growth, and leads to fungal cell death.

Dosage and Administration

The dosage should be taken exactly as prescribed by a registered physician.

• Usually administered orally twice daily after an initial loading dose (if prescribed)
• Dose may be adjusted based on body weight, liver function, and response to treatment
• Should be taken on an empty stomach or as directed by the physician
• Treatment must be completed as prescribed even if symptoms improve

Benefits of Vorifast Tablet

• Effective against a wide range of serious fungal infections
• Useful for both initial and maintenance therapy
• Can be used after injectable antifungal treatment
• Provides systemic antifungal coverage
• Helps control life-threatening fungal infections

Precautions

Use cautiously in:

• Patients with liver impairment
• Patients with heart rhythm disorders (QT prolongation risk)
• Kidney impairment
• Elderly or debilitated patients
• Pregnant or breastfeeding women unless clearly necessary

Regular monitoring of liver function, vision changes, and potential drug interactions is essential during therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Visual disturbances (blurred vision, altered color perception)
• Nausea and vomiting
• Headache
• Rash
• Abdominal pain
• Elevated liver enzymes
• Dizziness

Serious adverse effects such as severe liver toxicity, allergic reactions, or cardiac rhythm disturbances require immediate medical attention.

Storage

• Store below 30°C
• Protect from light and moisture
• Keep in a dry place
• Keep out of reach of children.