Venclax Tablet 10 mg contains Venetoclax, a targeted anticancer medicine belonging to the BCL-2 inhibitor class. It is used in the treatment of certain blood cancers by promoting the programmed death of cancer cells while sparing normal cells.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Venclax Tablet is indicated for:

• Chronic lymphocytic leukemia (CLL)
• Small lymphocytic lymphoma (SLL)
• Acute myeloid leukemia (AML) in combination therapy (as per oncology protocol)
• Other hematological malignancies as prescribed by a specialist

Mechanism of Action

Venetoclax selectively inhibits the BCL-2 protein, which helps cancer cells survive. By blocking this protein, it:

• Restores normal apoptosis (programmed cell death)
• Promotes death of malignant lymphocytes
• Reduces survival and proliferation of cancer cells

Dosage and Administration

• Taken orally once daily, as prescribed by an oncologist
• Dose is gradually increased according to a dose-escalation schedule
• Must be taken with food and water at the same time each day
• Tablets should be swallowed whole, not crushed or chewed
• Close monitoring is required during dose initiation

Benefits

• Targeted therapy for blood cancers
• Helps shrink lymph node enlargement and abnormal blood cell counts
• Improves disease control in CLL/SLL and AML
• Oral administration for convenient long-term use
• Can be used in combination with other anticancer drugs

Side Effects

Common side effects may include:

• Neutropenia (low white blood cells)
• Diarrhea
• Nausea
• Fatigue
• Upper respiratory infections

Serious side effects:

• Tumor lysis syndrome (rapid breakdown of cancer cells)
• Severe infections
• Anemia or thrombocytopenia
• Kidney function changes due to tumor lysis syndrome

Precautions and Warnings

• Initiation must be under strict oncology supervision
• High risk of tumor lysis syndrome—requires preventive measures and monitoring
• Regular blood tests are essential
• Use caution in patients with kidney or liver impairment
• Not recommended during pregnancy or breastfeeding
• Effective contraception is required during treatment and after therapy

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Venclax Tablet may interact with:

• Strong CYP3A inhibitors (increase toxicity risk)
• Strong CYP3A inducers (reduce effectiveness)
• Antifungal agents (azole class)
• Certain antibiotics and antiviral drugs

Dose adjustments may be required based on interactions.

Storage

• Store below 30°C in a dry place
• Protect from moisture and light
• Keep out of reach of children.