Ultrapime Injection 1 gm/vial contains Cefepime Hydrochloride, a fourth-generation cephalosporin antibiotic administered parenterally to treat severe bacterial infections. This injectable formulation is widely used in hospital settings for life-threatening or complicated infections caused by susceptible Gram-positive and Gram-negative bacteria, including strains resistant to third-generation cephalosporins.

Cefepime exhibits broad-spectrum bactericidal activity by inhibiting bacterial cell wall synthesis, leading to bacterial cell lysis and death. Its enhanced stability against beta-lactamases and improved penetration into body tissues make it particularly effective in managing severe respiratory tract infections, complicated urinary tract infections, skin infections, intra-abdominal infections, septicemia, and febrile neutropenia.

The 1 gm vial strength ensures rapid achievement of therapeutic plasma concentrations, allowing clinicians to administer effective doses for critically ill patients requiring aggressive therapy. Ultrapime Injection 1 gm/vial is ideal for intravenous therapy in both adults and pediatric patients, including those with serious systemic infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Fourth-generation Cephalosporin – Parenteral Antibiotic

Indications

Ultrapime Injection 1 gm/vial is indicated for the treatment of infections caused by susceptible microorganisms, including:

• Severe lower respiratory tract infections: Community-acquired and hospital-acquired pneumonia

• Complicated urinary tract infections (UTIs) and pyelonephritis

• Skin and soft tissue infections caused by susceptible Gram-positive and Gram-negative bacteria

• Intra-abdominal infections (used in combination with metronidazole)

• Septicemia and bacteremia requiring rapid systemic therapy

• Febrile neutropenia in immunocompromised patients at risk of bacterial infections

It is highly effective against pathogens such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp., including strains that produce beta-lactamases.

Pharmacology

Cefepime is a beta-lactam antibiotic that exerts its bactericidal action by binding to penicillin-binding proteins (PBPs), disrupting bacterial cell wall synthesis, and leading to cell lysis.

Pharmacokinetic Profile:

• Administration: Intravenous (IV) or intramuscular (IM)

• Absorption: Achieves high plasma and tissue concentrations rapidly after IV infusion

• Distribution: Widely distributed in body fluids and tissues, including lungs, kidneys, bile, and intra-abdominal areas

• Excretion: Approximately 85% excreted unchanged in urine via glomerular filtration and tubular secretion

• Half-life: 2 hours in patients with normal renal function

Spectrum of Activity: Broad-spectrum activity against Gram-positive and Gram-negative bacteria, including beta-lactamase-producing strains.

Mode of Action

• Binds to PBPs: Inhibits cross-linking of peptidoglycan in bacterial cell walls

• Bactericidal: Leads to bacterial cell death

• Rapid onset: Effective in controlling systemic infections in hospitalized patients

Dosage and Administration

Adults:

• Mild to moderate infections: 1 gm IV every 12 hours

• Severe infections or immunocompromised patients: 2 gm IV every 8–12 hours depending on infection severity and renal function

Pediatric Patients:

• Dose is weight-based; typically 50 mg/kg IV every 12 hours for moderate infections

• For severe infections, dosing may increase up to 150 mg/kg/day in divided doses

Renal Impairment:

• Adjust dosing for patients with creatinine clearance <60 mL/min to prevent drug accumulation and neurotoxicity

Administration Guidelines:

• Reconstitute with sterile water for injection, 0.9% sodium chloride, or 5% dextrose

• Administer IV slowly over 3–5 minutes or by IV infusion over 30 minutes

• IM injection is permissible in selected cases, avoiding intradermal administration

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to cefepime, other cephalosporins, or beta-lactam antibiotics

• History of severe anaphylactic reaction to penicillin

Side Effects

Common:

• Gastrointestinal: nausea, vomiting, diarrhea

• Injection site reactions: pain, inflammation, redness

• Mild rash or urticaria

Less Common:

• Neurotoxicity: seizures in patients with severe renal impairment if dosing is not adjusted

• Hematologic changes: eosinophilia, leukopenia

• Rare: hepatotoxicity, Clostridium difficile-associated diarrhea

Precautions and Warnings

• Monitor renal function and adjust dose in renal impairment

• Observe for signs of superinfection with prolonged use

• Use with caution in patients with a history of penicillin allergy

• Monitor for hematologic or hepatic abnormalities during extended therapy

Pregnancy and Lactation

• Pregnancy Category B: Animal studies show no risk; limited human data available

• Use only if the potential benefit outweighs the risk

• Cefepime is excreted in breast milk; use caution in nursing mothers

Storage Conditions

• Store at 20–25°C in a dry place, protected from light

• Keep vials out of reach of children

• Use reconstituted solution immediately or as per recommended storage conditions.