Indications

Twinvir Tablet 90 mg+400 mg is indicated for the treatment of chronic hepatitis C (CHC) genotype 1 infection in adult patients. It is used as an oral antiviral therapy to help eliminate hepatitis C virus and improve liver health.

Therapeutic Class

Hepatic viral infections (Hepatitis C)

Pharmacology

Twinvir Tablet is a fixed-dose combination of two direct-acting antiviral agents. One component is an HCV NS5A inhibitor, while the other is sofosbuvir, a nucleotide analog inhibitor of the HCV NS5B RNA-dependent polymerase. This dual mechanism interferes with viral replication at different stages of the hepatitis C virus life cycle.
After oral administration, peak plasma concentrations of the NS5A inhibitor are typically achieved within approximately 4 to 4.5 hours.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• One tablet containing 90 mg of Twinvir and 400 mg of sofosbuvir taken orally once daily

• Can be taken with or without food

Dose recommendations cannot be made for patients with severe renal impairment or end-stage renal disease.

Contraindications

Twinvir Tablet is contraindicated in patients with known hypersensitivity to Twinvir, sofosbuvir, or any other component of the formulation.

Drug Interactions

Coadministration with amiodarone is not recommended due to the risk of serious symptomatic bradycardia. Use with other medicinal products containing sofosbuvir is also not recommended.

Side Effects

The most commonly reported adverse reactions, occurring in 10% or more of patients, include:

• Fatigue

• Headache

• Nausea

• Diarrhea

• Insomnia

These effects were observed during treatment durations of 8, 12, or 24 weeks.

Pregnancy and Lactation

Twinvir Tablet is classified as Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
It is not known whether Twinvir or its metabolites are excreted in human breast milk, so caution should be exercised when administered to nursing mothers.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

Serious symptomatic bradycardia has been reported when this combination is used with amiodarone, especially in patients with underlying cardiac disease, those receiving beta-blockers, or those with advanced liver disease. If no alternative treatment options are available, close cardiac monitoring is recommended.

Use in Special Populations

• Pediatric patients: Safety and effectiveness have not been established

• Geriatric patients: No overall differences in safety or effectiveness compared to younger adults; no dosage adjustment is required

Storage Conditions

Store in a cool and dry place. Protect from light and moisture. Keep out of the reach of children.